Evidence map›Paper›PMID 36777748›Full record

ArticleCrohn's & colitis 3602020

Fecal Microbiota Transplantation for Ulcerative Colitis: An Evolving Therapy.

Ajit Sood, Arshdeep Singh, Vandana Midha, Ramit Mahajan, Dina Kao, David T Rubin, Charles N Bernstein

Abstract read
In one paragraph

Article in Crohn's & colitis 360, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  6. A practical approach to positioning therapies in ulcerative colitis.Journal of the Canadian Association of Gastroenterology · 2025
    Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ajit SoodDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India.
Arshdeep SinghDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India.ORCID 0000-0001-7163-0454
Vandana MidhaDepartment of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, India.
Ramit MahajanDepartment of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India.ORCID 0000-0001-6726-6151
Dina KaoDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
David T RubinInflammatory Bowel Disease Center, Department of Medicine, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-5647-1723
Charles N BernsteinUniversity of Manitoba IBD Clinical and Research Centre and Section of Gastroenterology, Department of Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0001-8041-3574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fecal microbiota transplantation (FMT) is currently an approved treatment for recurrent and refractory Clostridioides difficile infection. However, its use in ulcerative colitis is at an early stage and significant gaps remain in our understanding of the mechanisms and logistics of its practical application. Methods and results: This article aims to look into specific issues which remain unsettled for use of FMT in ulcerative colitis including donor and recipient selection, route of administration, and duration of therapy. We also discuss optimal ways to assess response to FMT and the current state of FMT regulations. In addition, we postulate the impact of diet on the microbiome profile of the donor and recipient. We also suggest a change in the nomenclature from FMT to fecal microbiome transfer. Conclusion: FMT is an evolving therapy. There are several considerations for its use in UC but its use and role should be directed by further clinical trials.

Indexed as

fecal microbial transplantationfecal microbiome transferrandomized controlled trialulcerative colitis

Identifiers

PMID36777748
PMCPMC9802301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.