ArticleCell genomics2021
Population genomics of the critically endangered kākāpō.
Article in Cell genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
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Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Genomic erosion in the assessment of species' extinction risk and recovery potential.The Journal of heredity · 2026Article
- Population Decline, Inbreeding and Hybridization Shape the Genetic Vulnerability of a Critically Endangered Seabird.Molecular ecology · 2026Article
- Targeted chromosomal sequencing of wild bonobos identifies a genetically distinct subpopulation east of the Lomami river.Genome biology · 2026Article
- Two Australian genome assemblies expand the genomic blueprint of giant kelp.BMC genomics · 2026Article
- Historically Small Population Size Limits Purging of Deleterious Mutations in a Conservation-Reliant Species, the Kirtland's Warbler.bioRxiv : the preprint server for biology · 2026Article
- Resequencing of 284 genomes reveals evolutionary history and hotspot of genetic diversity of the giant bamboos.Plant diversity · 2026Article
- Assessing the Genetic Health and Conservation Value of an Introduced Urban Population of a Critically Endangered Parrot.Evolutionary applications · 2026Article
- Pangolin museum genomics reveal the dynamic genetic consequences and extinction risk of the critically endangered Chinese pangolin.Molecular biology and evolution · 2026Article
- The relationship between genomic variation and genetic load: insights from small island populations.Heredity · 2026Article
- Chromosome-level genome and population resequencing reveal genetic diversity, demographic history, and climate risk in the East Asian relict treePlant diversity · 2026Article
- Genome-Wide Homozygosity Predicts Inbreeding Depression in the Hihi/Stitchbird (Evolutionary applications · 2026Article
- Genomic erosion across avian lineages in the context of their evolutionary history.Molecular biology and evolution · 2026Article
- Increased Genetic Load in Breed Chickens and Reduced Coding Content in Long ROH.Genome biology and evolution · 2026Article
- Article
- Targeted Chromosomal Sequencing of Wild Bonobos Identifies a Genetically Distinct Subpopulation East of the Lomami River.bioRxiv : the preprint server for biology · 2026Article
- Indigenous microorganisms and benefit sharing.FEMS yeast research · 2026Review
- Genome Shows no Recent Inbreeding in Near-Extinction Woolly Rhinoceros Sample Found in Ancient Wolf's Stomach.Genome biology and evolution · 2026Article
- Genomic Architecture of Inbreeding Depression Associated With Hatching Failure in an Endangered Parrot.Molecular ecology · 2026Article
- Decoding the genome of Brainea insignis reveals insights into fern evolution and conservation.Nature communications · 2025Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
40 authors.
Funding
Abstract
The kākāpō is a flightless parrot endemic to New Zealand. Once common in the archipelago, only 201 individuals remain today, most of them descending from an isolated island population. We report the first genome-wide analyses of the species, including a high-quality genome assembly for kākāpō, one of the first chromosome-level reference genomes sequenced by the Vertebrate Genomes Project (VGP). We also sequenced and analyzed 35 modern genomes from the sole surviving island population and 14 genomes from the extinct mainland population. While theory suggests that such a small population is likely to have accumulated deleterious mutations through genetic drift, our analyses on the impact of the long-term small population size in kākāpō indicate that present-day island kākāpō have a reduced number of harmful mutations compared to mainland individuals. We hypothesize that this reduced mutational load is due to the island population having been subjected to a combination of genetic drift and purging of deleterious mutations, through increased inbreeding and purifying selection, since its isolation from the mainland ∼10,000 years ago. Our results provide evidence that small populations can survive even when isolated for hundreds of generations. This work provides key insights into kākāpō breeding and recovery and more generally into the application of genetic tools in conservation efforts for endangered species.
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