Evidence map›Paper›PMID 36777574›Full record

ArticleACS omega2023

Systematic Design and Study of Star-like Polymeric Prodrug Unimolecular Micelles β-CD-P[CL-

Zexiong Yang, Haiyan Mai, Delin Wang, Teng He, Fang Chen, Chufen Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zexiong YangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou510006, PR China.
Haiyan MaiDepartment of Pharmacy, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou510630, PR China.
Delin WangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou510006, PR China.
Teng HeSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou510006, PR China.
Fang ChenSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou510006, PR China.
Chufen YangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou510006, PR China.ORCID https://orcid.org/0000-0003-0793-1302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unimolecular micelles composed of a single polymeric molecule have recently attracted significant attention in anti-cancer drug delivery due to their high thermodynamic stability and small particle sizes. Applying the prodrug strategy to unimolecular micelles may provide superior nano-drug carriers with simultaneous high stability, low drug leakage, and well-drug loading capacity. However, the formation mechanism of the unimolecular prodrug micelles, the superiority of the prodrug strategy, as well as the prodrug controlled release mechanism were scantily understood at the mesoscopic scale. In this work, dissipative particle dynamics mesoscopic simulations were employed to investigate the self-assembly behavior, formation conditions, drug distribution regularities, and the prodrug release process of the star-like polymeric prodrug unimolecular micelles formed by β-CD-P[CL-

Identifiers

PMID36777574
PMCPMC9910076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.