Evidence map›Paper›PMID 36777552›Full record

ArticleCrohn's & colitis 3602022

Development of a New Index to Assess Small Bowel Inflammation Severity in Crohn's Disease Using Magnetic Resonance Enterography.

Yoram Bouhnik, Catherine Le Berre, Magaly Zappa, Maïté Lewin, Mourad Boudiaf, Anne Marie Zagdanski, Eric Frampas, Ammar Oudjit, Béatrice Scotto, Muriel Tissier and 10 more

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In one paragraph

Article in Crohn's & colitis 360, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yoram BouhnikService de gastro-entérologie-MICI, AP-HP, Hôpital Beaujon, Clichy, France.
Catherine Le BerreInstitut des Maladies de l'Appareil Digestif, Nantes University Hospital, Nantes, France.ORCID https://orcid.org/0000-0002-1124-2019
Magaly ZappaService de radiologie, AP-HP, Hôpital Beaujon, Clichy, France.
Maïté LewinService de radiologie, AP-HP, Hôpital Paul Brousse, Villejuif, France.
Mourad BoudiafService de radiologie, AP-HP, Hôpital Cochin, Paris, France.
Anne Marie ZagdanskiService de radiologie, AP-HP, Hôpital Saint-Louis, Paris, France.
Eric FrampasService central de radiologie et imagerie médicale, Nantes University Hospital, Nantes, France.
Ammar OudjitService de radiologie, AP-HP, Hôpital Cochin, Paris, France.
Béatrice ScottoService de radiologie, University Hospital of Tours, Tours, France.
Muriel TissierService de radiologie, AP-HP, Hôpital Bichat, Paris, France.
Laurence AnnetMedical Imaging Department, Cliniques universitaires Saint-Luc, Université catholique de Louvain (UCL), Brussels, Belgium.
Sophie AufortService de radiologie, Clinique du Parc, Castelnau Le Lez, France.
Thierry YzetService de radiologie digestive, University Hospital of Amiens-Picardie, Hôpital Sud, Amiens, France.
Muriel CuilleronService de radiologie, University Hospital of Saint-Etienne, Saint-Etienne, France.
Guillaume BaudinService d'imagerie diagnostique et interventionnelle, Hôpital de L'Archet, Nice, France.
Vered AbitbolService d'hépato-gastro-entérologie, AP-HP, Hôpital Cochin, Paris, France.
Jacques CosnesService de gastroentérologie, AP-HP, Hôpital Saint-Antoine, Paris, France.
Arnaud BourreilleInstitut des Maladies de l'Appareil Digestif, Nantes University Hospital, Nantes, France.
Jean Yves MaryUMR-S-1153 Inserm, Denis Diderot-Paris 7 University, Hôpital Saint-Louis, Paris, France.
GETAID CDMRIS Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The severity of small bowel (SB) inflammation in Crohn's disease (CD) patients is a key component of the therapeutic choice. We aimed to develop a SB-CD Magnetic Resonance Enterography (MRE) index of Inflammation Severity (CDMRIS). Methods: Each gastroenterologist/radiologist pair in 13 centers selected MREs from 6 patients with SB-CD stratified on their perceived MRE inflammation severity. The 78 blinded MREs were allocated through balanced incomplete block design per severity stratum to these 13 pairs for rating the presence/severity of 13 preselected items for each SB 20-cm diseased segment. Global inflammation severity was evaluated using a 100-cm visual analog scale. Reproducibility of recorded items was evaluated. The CDMRIS was determined through linear mixed modeling as a combination of the numbers of segments with lesions highly correlated to global inflammation severity. Results: Four hundred and forty-two readings were available. Global inflammation severity mean ± SD was 21.0 ± 16.2. The independent predictors explaining 54% of the global inflammation severity variance were the numbers of segments with T1 mild-moderate and severe intensity of enhancement, deep ulceration without fistula, comb sign, fistula, and abscess. Unbiased correlation between CDMRIS and global inflammation severity was 0.76. Conclusions: The CDMRIS is now available to evaluate the severity of SB-CD inflammation. External validation and sensitivity-to-change are mandatory next steps.

Indexed as

CDMRISCrohnMREsmall bowel

Identifiers

PMID36777552
PMCPMC9802414

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.