Evidence map›Paper›PMID 36777518›Full record

ArticleAmerican journal of cancer research2023

Long non-coding RNA PSMG3 Antisense RNA 1 is correlated with oral squamous cell carcinoma and regulates cancer cell proliferation by targeting premature microRNA-141.

Shaobo Ouyang, Feng Xuan, Xianhua Zhang, Wei Yuan, Xin Fan, Jun Wang

Abstract read
PubMed Full text at PMC
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Article in American journal of cancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shaobo OuyangDepartment of Oral Prosthodontics, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases 49 Fuzhou Road, Donghu District, Nanchang 330006, Jiangxi, P. R. China.
Feng XuanDepartment of Oral Prosthodontics, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases 49 Fuzhou Road, Donghu District, Nanchang 330006, Jiangxi, P. R. China.
Xianhua ZhangDepartment of Oral Prosthodontics, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases 49 Fuzhou Road, Donghu District, Nanchang 330006, Jiangxi, P. R. China.
Wei YuanDepartment of Oral Prosthodontics, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases 49 Fuzhou Road, Donghu District, Nanchang 330006, Jiangxi, P. R. China.
Xin FanDepartment of Oral Prosthodontics, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine, Jiangxi Province, Jiangxi Province Clinical Research Center for Oral Diseases 49 Fuzhou Road, Donghu District, Nanchang 330006, Jiangxi, P. R. China.
Jun WangOral and Maxillofacial Surgery, Second Affiliated Hospital of Nanchang University No. 1 Minde Road, Donghu District, Nanchang 330008, Jiangxi, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is common worldwide. In this study, the interaction of microRNA-141 (miR-141) with long non-coding RNA (lncRNA) PSMG3 Antisense RNA 1 (PSMG3-AS1) in OSCC was explored. RT-qPCR was used to analyze the expression of PSMG3-AS1 and miR-141 (both mature and premature) in OSCC. Nuclear fractionation assay was applied to detect PSMG3-AS1 in subcellular locations. RNA pull-down assay was performed to evaluate the binding of miR-141 to PSMG3-AS1. Overexpression assay followed by RT-qPCR was performed to explore the role of PSMG3-AS1 in maturation of miR-141. The function of PSMG3-AS1 and miR-141 in regulating OSCC cell proliferation was assessed by BrdU assay. The results showed that PSMG3-AS1 was highly upregulated in OSCC and miR-141 was downregulated in OSCC. However, no alteration in the expression of premature miR-141 was observed in OSCC. Premature miR-141 was found to directly bind to PSMG3-AS1. Overexpression of PSMG3-AS1 suppressed the maturation of miR-141. PSMG3-AS1 increased OSCC cell proliferation and tumor growth and suppressed the inhibitory role of miR-141 in cell proliferation and tumor growth. Therefore, PSMG3-AS1 may inhibit the maturation of miR-141 to promote OSCC cell proliferation.

Indexed as

cell proliferationmiR-141miRNA maturationoral squamous cell carcinomaPSMG3-AS1

Identifiers

PMID36777518
PMCPMC9906088

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