Evidence map›Paper›PMID 36777417›Full record

ArticleCrohn's & colitis 3602022

Bezlotoxumab Therapy for Recurrent

Aaron Fein, Cody Kern, Terrance Barrett, Courtney Perry

Abstract read
In one paragraph

Article in Crohn's & colitis 360, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Therapeutics involved in managing initial and recurrentWorld journal of gastrointestinal pharmacology and therapeutics · 2024
    Review
  4. Bezlotoxumab for prevention ofAnnals of gastroenterology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aaron FeinDepartment of Internal Medicine, University of Kentucky Medical Center, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-2254-4466
Cody KernDepartment of Digestive Disease and Nutrition, University of Kentucky Medical Center, Lexington, Kentucky, USA.
Terrance BarrettDepartment of Digestive Disease and Nutrition, University of Kentucky Medical Center, Lexington, Kentucky, USA.
Courtney PerryDepartment of Digestive Disease and Nutrition, University of Kentucky Medical Center, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0001-6177-3128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: A single infusion of bezlotoxumab @ 10mg/kg was given with fidaxomicin 200mg for 10 days in a patient with rCDI and ulcerative colitis. Results: The patient's symptoms improved, inflammatory markers normalized, and she has remained asymptomatic for twelve months. Conclusions: This case supports the findings in the MODIFY I/II trials that Bezlotoxumab is a viable treatment option of rCDI in IBD patients.

Indexed as

bezlotoxumabClostridium difficileulcerative colitis

Identifiers

PMID36777417
PMCPMC9802285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.