ArticleLancet regional health. Americas2022
Invasive pneumococcal disease and long-term outcomes in children: A 20-year population cohort study.
Article in Lancet regional health. Americas, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Mapping infant streptococcal mortality burden in low- and middle-income countries: temporal trends, geospatial patterns, and socioeconomic determinants.European journal of pediatrics · 2026Article
- Distribution ofVaccines · 2026Review
- Machine learning and meningitis prediction in pediatric invasive pneumococcal disease: a retrospective single-center study.BMC infectious diseases · 2026Article
- Impact of sequential pediatric pneumococcal conjugate vaccination (PCV10/PCV13/PCV10) on serotype distribution and antimicrobial resistance in invasive and non-invasiveFrontiers in microbiology · 2026Article
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- Antimicrobial resistance among children in Southeast Asia: a systematic review.BMJ public health · 2025Article
- Pediatric invasive pneumococcal disease in Bolívar, Colombia: a descriptive cross-sectional study.Le infezioni in medicina · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although vaccination against Methods: Analysis of Findings: Proportionally more deaths occurred in cases (4.8 deaths/1000 person-years (PY)) than controls (2.7 deaths/1000 PY), leading to a significant adjusted hazard ratio (aHR) of 1.80 (95% CI 1.22-2.64). This increased risk of death was influenced primarily by short-term mortality (319 vs 36 deaths/1000 PY in cases vs controls respectively, aHR 8.78 [95% CI 3.33-23.18]), as no differences were seen in intermediate (14 vs 7 deaths/1000 PY; aHR 2.03, 95% CI 0.41-10.04) or long-term time intervals (2.4 vs 2.3 deaths/1000 PY, aHR 1.03, 95% CI 0.63-1.69). Interpretation: IPD continues to negatively impact survival in children despite vaccination. Although long-term impact on mortality and hospitalisations may not be substantial, the immediate effects of IPD are significant. Funding: This work was supported by grants-in-aid from Pfizer Canada and Wyeth Canada Inc all to GJT.
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Registered trials
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