Evidence map›Paper›PMID 36777264›Full record

ArticleCrohn's & colitis 3602021

Inflammatory Bowel Disease Patients' Perspectives of Clinical Trials: A Global Quantitative and Qualitative Analysis.

David T Rubin, Laurent Peyrin-Biroulet, Walter Reinisch, Swati Tole, Laura Sullivan, K T Park, Miguel Regueiro

Abstract read
In one paragraph

Article in Crohn's & colitis 360, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David T RubinDepartment of Medicine and Biological Sciences, University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-5647-1723
Laurent Peyrin-BirouletDepartment of Gastroenterology, Nancy University Hospital, Vandoeuvre-Les-Nancy, France.
Walter ReinischDepartment of Medicine, Medical University of Vienna, Vienna, Austria.
Swati ToleClinical Science, Genentech, Inc., South San Francisco, California, USA.
Laura SullivanClinical Science, Genentech, Inc., South San Francisco, California, USA.
K T ParkClinical Science, Genentech, Inc., South San Francisco, California, USA.
Miguel RegueiroDepartment of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-7681-8111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite recent progress, inflammatory bowel disease (IBD) therapies with pronounced long-term efficacy and improved safety are needed. IBD clinical trials face challenges with patient recruitment because of study designs, competitive or overlapping trials, and limited numbers of eligible patients. We aimed to better understand patients' awareness of, attitudes toward, and experience with IBD clinical trials. Methods: This multinational, cross-sectional cohort study of adults with IBD recruited online consisted of 2 components: a quantitative 15-minute online survey completed by all participants and a qualitative 30-minute telephone interview completed by a subset of patients from the United States. Results: Quantitative survey respondents ( Conclusions: Opportunities to improve participation in IBD trials include improved communication with health care providers, further patient education, and alternative trial designs. Ultimately, a better understanding of the patient perspective will be important for more informed patients and more successful recruitment and enrollment.

Indexed as

Crohn’s diseasepatient preferencepatient surveyulcerative colitis

Identifiers

PMID36777264
PMCPMC9802428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.