Evidence map›Paper›PMID 36777254›Full record

ArticleFrontiers in bioengineering and biotechnology2023

Peptide linker increased the stability of pneumococcal fusion protein vaccine candidate.

Luciano Zane, Stefanie Kraschowetz, Monalisa Martins Trentini, Vitor Dos Santos Alves, Sergio Carneiro Araujo, Cibelly Goulart, Luciana Cezar de Cerqueira Leite, Viviane Maimoni Gonçalves

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Synthetic Biology Approaches to Enzymology in Food and Agriculture Systems.Journal of agricultural and food chemistry · 2026
    Review
  4. Review
  5. Article
  6. Human vaccines & immunotherapeutics · 2025
    Review
  7. Novel processes to obtain pneumococcal surface proteins for vaccines.Applied microbiology and biotechnology · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luciano ZaneLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.
Stefanie KraschowetzLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.
Monalisa Martins TrentiniLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.
Vitor Dos Santos AlvesLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.
Sergio Carneiro AraujoLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.
Cibelly GoulartLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.
Luciana Cezar de Cerqueira LeiteLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.
Viviane Maimoni GonçalvesLaboratory of Vaccine Development, Butantan Institute, Sao Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

mouse immunizationpneumolysinprotease detectionprotein structural modelPspArecombinant Escherichia colispacerStreptococcus pneumoniae

Identifiers

PMID36777254
PMCPMC9909212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.