Evidence map›Paper›PMID 36777181›Full record

ArticleCell genomics2023

Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay.

Kousuke Mouri, Hannah B Dewey, Rodrigo Castro, Daniel Berenzy, Susan Kales, Ryan Tewhey

Abstract read
In one paragraph

Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kousuke MouriThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Hannah B DeweyThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Rodrigo CastroThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Daniel BerenzyThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Susan KalesThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Ryan TewheyThe Jackson Laboratory, Bar Harbor, ME 04609, USA.

Funding

Comprehensive functional characterization and dissection of noncoding regulatory elements and human genetic variationUM1HG009435 · NHGRI · BROAD INSTITUTE, INC. · PI SABETI, PARDIS CHRISTINE · 2017 to 2021
$6.6M
Functional Mapping of Enhancer Conservation Between Species to Enable Mechanistic Insights into Polygenic DiseaseR35HG011329 · NHGRI · JACKSON LABORATORY · PI TEWHEY, RYAN · 2021 to 2025
$2.6M
Massively Parallel Phenotypic Characterization of Non-coding Genetic VariationR00HG008179 · NHGRI · JACKSON LABORATORY · PI TEWHEY, RYAN · 2018 to 2020
$747k
NHGRI NIH HHS R00 HG008179NHGRI NIH HHS R35 HG011329NHGRI NIH HHS UM1 HG009435
6 · The paper itself

Abstract

Both upregulation and downregulation by

Indexed as

gene regulationhuman variantMPRARE1RESTsilencertranscription factor

Identifiers

PMID36777181
PMCPMC9903721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.