ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- The design of embedded pragmatic clinical trials: methodological developments and statistical lessons learned from the first cycle of the NIA IMPACT collaboratory.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A meta-review of patient engagement, shared decision-making, and factors influencing equity-deserving populations' participation in clinical trials.Research involvement and engagement · 2026Review
- The clinical and cost-effectiveness of improving sleep via carer delivered strategies in people with dementia: the DREAMS START parallel multi-centre RCT.Health technology assessment (Winchester, England) · 2026Article
- Widely used but weakly studied: a research agenda for Memory Cafés.Innovation in aging · 2026Article
- A cognitive screening program in community-based medical clinics to facilitate Latino participation in Alzheimer's disease research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Barriers and Facilitators for Equitable Clinical Research Among Pragmatic Trialists: A Qualitative Study.Pragmatic and observational research · 2026Article
- Sleep Disturbances and Dementia in the UK South Asian Community: A Qualitative Study to Inform Future Adaptation of the DREAMS-START Intervention.Geriatrics (Basel, Switzerland) · 2025Article
- Equity of participants in clinical trials in critical care and perioperative medicine research: a systematic review.BJA open · 2025Review
- Advancing health equity: Why guideline development must prioritize fairness and justice.Clinical and public health guidelines · 2025Article
- Article
- Recurring and Emerging Ethical Issues in Pragmatic Clinical Trials.Circulation. Cardiovascular quality and outcomes · 2024Article
- Assessing treatment effect heterogeneity in the presence of missing effect modifier data in cluster-randomized trials.Statistical methods in medical research · 2024Article
- The Case for Conducting Pragmatic Dementia Care Trials in Medicaid Home and Community-Based Service Settings.Journal of the American Medical Directors Association · 2023Article
- Career development in pragmatic clinical trials to improve care for people living with dementia.Journal of the American Geriatrics Society · 2023Article
- Considerations When Designing and Implementing Pragmatic Clinical Trials That Include Older Hispanics.Ethnicity & disease · 2023Article
- A fresh look at the multi-level social determinants of disparities in Alzheimer's disease and related dementias.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
Abstract
Introduction: To improve dementia care delivery for persons across all backgrounds, it is imperative that health equity is integrated into pragmatic trials. Methods: We reviewed 62 pragmatic trials of people with dementia published 2014 to 2019. We assessed health equity in the objectives; design, conduct, analysis; and reporting using PROGRESS-Plus which stands for Place of residence, Race/ethnicity, Occupation, Gender/sex, Religion, Education, Socioeconomic status, Social capital, and other factors such as age and disability. Results: Two (3.2%) trials incorporated equity considerations into their objectives; nine (14.5%) engaged with communities; 4 (6.5%) described steps to increase enrollment from equity-relevant groups. Almost all trials (59, 95.2%) assessed baseline balance for at least one PROGRESS-Plus characteristic, but only 10 (16.1%) presented subgroup analyses across such characteristics. Differential recruitment, attrition, implementation, adherence, and applicability across PROGRESS-Plus were seldom discussed. Discussion: Ongoing and future pragmatic trials should more rigorously integrate equity considerations in their design, conduct, and reporting. Highlights: Few pragmatic trials are explicitly designed to inform equity-relevant objectives.Few pragmatic trials take steps to increase enrollment from equity-relevant groups.Disaggregated results across equity-relevant groups are seldom reported.Adherence to existing tools (e.g., IMPACT Best Practices, CONSORT-Equity) is key.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.