ArticleRespirology case reports2023
A case of disseminated intravascular coagulation following tumour lysis syndrome due to small cell carcinoma of the lung.
Article in Respirology case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Treatment-emergent coagulopathy during azacitidine/venetoclax induction in AML.Blood neoplasia · 2026Article
- Tumor Lysis Syndrome in a Patient with BRAFInternal medicine (Tokyo, Japan) · 2025Article
- [Acute promyelocytic leukemia with disseminated intravascular coagulation: a case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Review
- A case of disseminated intravascular coagulation following tumour lysis syndrome due to small cell carcinoma of the lung.Respirology case reports · 2023Article
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5 authors.
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Abstract
A 64-year-old man was diagnosed with small cell lung cancer (SCLC) with multiple bone and liver metastases and bone marrow metastases. Spontaneous tumour lysis syndrome (TLS) was observed before starting chemotherapy with carboplatin, etoposide, and atezolizumab. The tumour further collapsed, and the patient developed disseminated intravascular coagulation (DIC) on day 4 of chemotherapy. The patient was successfully treated with intravenous hydration and rasburicase for TLS and subcutaneous unfractionated heparin for DIC. A large amount of tissue factor may be released in TLS, which could induce DIC. However, to the best of our knowledge, this is the first report of DIC following TLS in a case of SCLC. DIC following TLS in SCLC is a rare but life-threatening oncologic complication. Therefore, clinicians should be aware of this possibility when treating patients with advanced SCLC.
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