Evidence map›Paper›PMID 36776991›Full record

ArticleCell genomics2022

Taiwan Biobank: A rich biomedical research database of the Taiwanese population.

Yen-Chen Anne Feng, Chia-Yen Chen, Tzu-Ting Chen, Po-Hsiu Kuo, Yi-Hsiang Hsu, Hwai-I Yang, Wei J Chen, Ming-Wei Su, Hou-Wei Chu, Chen-Yang Shen and 3 more

Abstract read
In one paragraph

Article in Cell genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Does ambient PMBMC medicine · 2025
    Pooled it
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  18. Genetic basis of Asian diabetes.Journal of diabetes investigation · 2026
    Review
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  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yen-Chen Anne FengInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Chia-Yen ChenBiogen, Cambridge, MA, USA.
Tzu-Ting ChenCenter for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.
Po-Hsiu KuoInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Yi-Hsiang HsuMarcus Institute for Aging Research and Harvard Medical School, Boston, MA, USA.
Hwai-I YangGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Wei J ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Ming-Wei SuTaiwan Biobank, Academia Sinica, Taipei, Taiwan.
Hou-Wei ChuTaiwan Biobank, Academia Sinica, Taipei, Taiwan.
Chen-Yang ShenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Tian GeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Hailiang HuangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yen-Feng LinCenter for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.

Funding

2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7M
Identifying Osteoporosis Genes by Whole Genome Sequencing and Functional Validation in Zebra FishR01AR072199 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI HSU, YI-HSIANG · 2017 to 2022
$3.2M
Exploring the genetic basis of AD progressionR00AG054573 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GE, TIAN · 2020 to 2022
$732k
Genetics and gene regulation in the inflammatory bowel diseasesK01DK114379 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, HAILIANG · 2017 to 2021
$632k
Improving Methods and Practices for Trans-Ethnic Genetic StudiesR56HG012354 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI GE, TIAN · 2022 to 2022
$475k
NHGRI NIH HHS R56 HG012354NIAMS NIH HHS R01 AR072199NIA NIH HHS R00 AG054573NIDDK NIH HHS K01 DK114379NIMH NIH HHS U01 MH109539
6 · The paper itself

Abstract

The Taiwan Biobank (TWB) is an ongoing prospective study of >150,000 individuals aged 20-70 in Taiwan. A comprehensive list of phenotypes was collected for each consented participant at recruitment and follow-up visits through structured interviews and physical measurements. Biomarkers and genetic data were generated from blood and urine samples. We present here an overview of TWB's genetic data quality, population structure, and familial relationship, which consists of predominantly Han Chinese ancestry, and highlight its important attributes and genetic findings thus far. A linkage to Taiwan's National Health Insurance database of >25 years and other registries is underway to enrich the phenotypic spectrum and enable deep and longitudinal genetic investigations. TWB provides one of the largest biobank resources for biomedical and public health research in East Asia that will contribute to our understanding of the genetic basis of health and disease in global populations through collaborative studies with other biobanks.

Identifiers

PMID36776991
PMCPMC9903657

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.