ArticleFrontiers in immunology2023
Smoking and coronary artery disease risk in patients with diabetes: A Mendelian randomization study.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Association of cigarette smoking intensity and pack-years with metabolic syndrome: A cross-sectional study.Bioinformation · 2026Article
- Integrative machine learning and Mendelian randomization identify causal laboratory biomarkers for coronary artery lesions in Kawasaki disease: a prospective study.Frontiers in genetics · 2025Article
- Prognostic factors of MINOCA and their possible mechanisms.Preventive medicine reports · 2024Review
- Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease.BMC medicine · 2023Article
- Genetically predicted lifestyle factors, socioeconomic status and risk of coronary artery disease in individuals with diabetes: a Mendelian randomization study.Frontiers in public health · 2023Article
- Determination of genetic correlation between tobacco smoking and coronary artery disease.Frontiers in psychiatry · 2023Article
- Gut microbiota and autism spectrum disorders: a bidirectional Mendelian randomization study.Frontiers in cellular and infection microbiology · 2023Article
- Mendelian randomization implicates circulating plasma proteins in gout risk and identifies candidate therapeutic targets.International journal of immunopathology and pharmacologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous observational studies have shown an association between smoking and coronary artery disease (CAD) in patients with diabetes. Whether this association reflects causality remains unestablished. This study aimed to explore the causal effect of smoking on CAD in patients with diabetes. Methods: Genetic signatures for smoking were extracted from a large genome-wide association study (GWAS), consisted of up to 1.2 million participants. Four smoking phenotypes were included: smoking initiation, cigarettes per day, age at initiation of regular smoking, and smoking cessation. Genetic associations with CAD in patients with diabetes were extracted from another GWAS, which included 15,666 participants (3,968 CAD cases and 11,696 controls). The analyses were performed using the univariable and multivariable Mendelian randomization (MR) method. Results: MR analysis revealed that smoking initiation was positively related to CAD risk in patients with diabetes (OR = 1.322, 95% CI = 1.114 - 1.568, Conclusions: This study supported the effect of smoking initiation on the risk of CAD in patients with diabetes.
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