Evidence map›Paper›PMID 36776833›Full record

ArticleFrontiers in immunology2023

Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4.

Katie Fisher, Timothy E Schlub, Zoe Boyer, Thomas A Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M Hecht, Steven G Deeks, Sharon R Lewin, Sarah Palmer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Katie FisherCentre for Virus Research, The Westmead Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
Timothy E SchlubSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Zoe BoyerCentre for Virus Research, The Westmead Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
Thomas A RasmussenDepartment of Infectious Diseases, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Ajantha RhodesDepartment of Infectious Diseases, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Rebecca HohDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, United States.
Frederick M HechtDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, United States.
Steven G DeeksDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco, San Francisco, CA, United States.
Sharon R LewinDepartment of Infectious Diseases, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Sarah PalmerCentre for Virus Research, The Westmead Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.
The University of Sydney · AUThe University of Melbourne · AUUniversity of California, San Francisco · USAarhus University Hospital · DKSan Francisco General Hospital · USWestmead Institute · AU

Funding

Delaney AIDS Research Enterprise to Cure HIVUM1AI164560 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS, Sharon Ruth Lewin · 2021 to 2026
$32.0M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
NIAID NIH HHS UM1 AI126611NIAID NIH HHS UM1 AI164560
6 · The paper itself

Abstract

Introduction: HIV-1 persists in resting CD4 Methods: We obtained peripheral blood from 16 HIV-1-infected participants, and paired lymph node from four of these participants, during effective ART. Memory CD4 Results and Discussion: In peripheral blood, we observed that proviruses found within PD-1

Indexed as

HIV-1HIV InfectionsHIV SeropositivityBiomarkersCD4-Positive T-LymphocytesCTLA-4 AntigenHumansProgrammed Cell Death 1 ReceptorProvirusesBiomarkersCTLA-4 AntigenProgrammed Cell Death 1 ReceptorCTLA-4genetically-intactHIV-1PD-1persistenceproviruses

Identifiers

PMID36776833
PMCPMC9909745
OpenAlexW4318067498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.