Evidence map›Paper›PMID 36776816›Full record

ArticleArXiv2023

Fiber Organization has Little Effect on Electrical Activation Patterns during Focal Arrhythmias in the Left Atrium.

Jiyue He, Arkady M Pertsov, Elizabeth M Cherry, Flavio H Fenton, Caroline H Roney, Steven A Niederer, Zirui Zang, Rahul Mangharam

Open access · greenAbstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jiyue HeDepartment of Electrical and Systems Engineering, University of Pennsylvania, USA.
Arkady M PertsovDepartment of Pharmacology, Upstate Medical University, USA.
Elizabeth M CherrySchool of Computational Science and Engineering, Georgia Institute of Technology, USA.
Flavio H FentonSchool of Physics, Georgia Institute of Technology, USA.
Caroline H RoneySchool of Engineering and Materials Science, Queen Mary University of London, UK.
Steven A NiedererSchool of Biomedical Engineering and Imaging Sciences, King's College London, UK.
Zirui ZangDepartment of Electrical and Systems Engineering, University of Pennsylvania, USA.
Rahul MangharamDepartment of Electrical and Systems Engineering, University of Pennsylvania, USA.
University of Pennsylvania · USGeorgia Institute of Technology · USKing's College London · GBQueen Mary University of London · GBSUNY Upstate Medical University · US

Funding

Integrative High-Resolution Experimental and Multiscale Modeling of Arrhythmias to Optimize Low Energy Anti-fibrillation Pacing (LEAP)R01HL143450 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Flavio H Fenton · 2018 to 2026
$3.2M
NHLBI NIH HHS R01 HL143450
6 · The paper itself

Abstract

Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in clinical practice due to limited availability of tissue and cellular scale data. One such limitation is obtaining information about myocardial fiber organization in the clinical setting. In this study, we investigated a chimeric model of the left atrium utilizing clinically derived patient-specific atrial geometry and a realistic, yet foreign for a given patient fiber organization. We discovered that even significant variability of fiber organization had a relatively small effect on the spatio-temporal activation pattern during regular pacing. For a given pacing site, the activation maps were very similar across all fiber organizations tested.

Indexed as

Cardiac electrical activation propagationFiber organizationFocal arrhythmia activation patternHeart modelingLeft atriumPatient-specific

Identifiers

PMID36776816
PMCPMC9915751
OpenAlexW4307928438

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.