Evidence map›Paper›PMID 36776768›Full record

ArticleProceedings. IEEE International Conference on Bioinformatics and Biomedicine2022

Effective Subject Representation based on Multi-omics Disease Networks using Graph Embedding.

Sundous Hussein, Thao Vu, Leslie Lange, Russell P Bowler, Katerina J Kechris, Farnoush Banaei-Kashani

Abstract read
In one paragraph

Article in Proceedings. IEEE International Conference on Bioinformatics and Biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sundous HusseinDepartment of Computer Science and Engineering, University of Colorado Denver, Denver, CO, USA.
Thao VuDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Leslie LangeDivision of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Russell P BowlerDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Katerina J KechrisDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Farnoush Banaei-KashaniDepartment of Computer Science and Engineering, University of Colorado Denver, Denver, CO, USA.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Biomarker of Lung Disease in African AmericansR01HL137995 · NHLBI · NATIONAL JEWISH HEALTH · PI BOWLER, RUSSELL PAUL, KECHRIS-MAYS, KATHERINA · 2018 to 2021
$3.4M
Multi-omic networks associated with COPD progression in TOPMed CohortsR01HL152735 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BANAEI-KASHANI, FARNOUSH, BOWLER, RUSSELL PAUL · 2020 to 2023
$3.1M
NHLBI NIH HHS R01 HL137995NHLBI NIH HHS R01 HL152735NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

The study of complex behavior of biological systems has become increasingly dependent on evolutionary network modeling. In particular, multi-omics networks capture interactions between biomolecules such as proteins and metabolites, providing a basis for predicting relationships between such biomolecules and various phenotypic traits of complex diseases. In this paper, we introduce an integrative framework that given a multi-omics network representing a cohort of subjects, learns expressive representations for network nodes, and combines the learned nodes representations with the biological profiles of individual subjects for enriched representation of the subjects. With extensive empirical evaluation using real-world multi-omics networks, we show that our proposed framework significantly outperforms existing and baseline methods in terms of subject representation accuracy, particularly when the multi-omics network representing the cohort is sparse and structured and therefore, more informative.

Indexed as

Graph Representation LearningMulti-omics NetworksNode EmbeddingSubject Representation

Identifiers

PMID36776768
PMCPMC9916186

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.