Evidence map›Paper›PMID 36776720›Full record

ArticleExposure and health2022

Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.

Margaret R Karagas, Susan McRitchie, Anne G Hoen, Cindy Takigawa, Brian Jackson, Emily R Baker, Juliette Madan, Susan J Sumner, Wimal Pathmasiri

Open access · greenAbstract read
In one paragraph

Article in Exposure and health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Susan McRitchieNutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anne G HoenDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Cindy TakigawaDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Brian JacksonDepartment of Earth Sciences, Dartmouth College, Hanover, NH, USA.
Emily R BakerDepartment of Obstetrics and Gynecology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Juliette MadanDepartment of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Susan J SumnerNutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wimal PathmasiriNutrition Research Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Dartmouth College · USUniversity of North Carolina at Chapel Hill · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI CHRISTENSEN, BROCK CLARKE · 2013 to 2022
$23.7M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUG3OD023275 · OD · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA, MADAN, JULIETTE · 2016 to 2024
$17.9M
RTI's Regional Comprehensive Metabolomics Resource CenterU24DK097193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUMNER, SUSAN J · 2012 to 2017
$9.8M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI MURRAY, CAROLYN J · 2013 to 2018
$4.7M
Multi-omic Functional Integration Using NetworksR01LM012723 · NLM · DARTMOUTH COLLEGE · PI HOEN, ANNE GATEWOOD · 2017 to 2020
$1.4M
NCI NIH HHS P30 CA023108NIDDK NIH HHS P30 DK056350NIDDK NIH HHS U24 DK097193NIEHS NIH HHS P01 ES022832NIGMS NIH HHS P20 GM104416NIH HHS UG3 OD023275NIH HHS UH3 OD023275NLM NIH HHS R01 LM012723
6 · The paper itself

Abstract

In utero and early life exposure to inorganic arsenic (iAs) alters immune response in experimental animals and is associated with an increased risk of infant infections. iAs exposure is related to differences in the gut microbiota diversity, community structure, and the relative abundance of individual microbial taxa both in laboratory and human studies. Metabolomics permits a direct measure of molecular products of microbial and host metabolic processes. We conducted NMR metabolomics analysis on infant stool samples and quantified the relative concentrations of 34 known microbial-related metabolites. We examined these metabolites in relation to both in utero and infant log

Indexed as

ArsenicIn utero exposureMetabolomicsPostnatal exposure

Identifiers

PMID36776720
PMCPMC9918239
OpenAlexW4210347084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.