ArticleCardiology and cardiovascular medicine2023
Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration.
Article in Cardiology and cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers.
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Who cites it
235 citing papers in PubMed.
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- Study of the potential protective efficacy of lactoferrin on indomethacin-induced gastric fundic mucosal injury in rats.Journal of molecular histology · 2026Article
- Objective Tongue-Function Outcomes After Lingual Frenotomy with Adjunctive Myofascial Rehabilitation: A Retrospective Observational Longitudinal Study.Journal of clinical medicine · 2026Article
- Late-Onset Preeclampsia Is Linked to Extensive Remodeling of the Placental Extracellular Matrix.Medical sciences (Basel, Switzerland) · 2026Observational
175 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
The structure of connective tissues including cartilage, tendons, and ligaments as well as many organs, like the skin, heart, liver, kidney, lungs, blood vessels, and bones, depend on collagen. The bulk of the network of structural proteins that make up the extracellular matrix of the heart is composed of collagen type I and type III, which provide structural support for the muscle cells and are crucial for cardiac function. The prognosis and progression of a disease or diseased state may be significantly impacted by the upregulation or downregulation of the collagen types, particularly Col I and Col III. For example, increasing Col I protein levels may impose increasing myocardial stiffness, impairing the diastolic and systolic function of the myocardium. Collagen I is a stiff fibrillar protein that gives tensile strength, whereas Col III produces an elastic network that stores kinetic energy as an elastic rebound. These two collagen proteins have distinct physical properties in nature. Therefore, the control of Col I and Col III as well as the potential relevance of the Col I/Col III ratio in many biological processes serve as the foundation for this comprehensive review article.
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Registered trials
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