Evidence map›Paper›PMID 36776530›Full record

ArticleTherapeutic advances in neurological disorders2023

Corneal axonal loss as an imaging biomarker of neurodegeneration in multiple sclerosis: a longitudinal study.

Ioannis N Petropoulos, Fatima Al-Shibani, Gulfidan Bitirgen, Georgios Ponirakis, Adnan Khan, Hoda Gad, Ziyad R Mahfoud, Heba Altarawneh, Muhammad Hassan Rehman, Karen John and 15 more

Abstract read
In one paragraph

Article in Therapeutic advances in neurological disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ioannis N PetropoulosDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Fatima Al-ShibaniDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Gulfidan BitirgenDepartment of Ophthalmology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Georgios PonirakisDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Adnan KhanDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Hoda GadDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Ziyad R MahfoudDivision of Medical Education, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Heba AltarawnehDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Muhammad Hassan RehmanDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Karen JohnDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Dhabia Al-MerekhiDivision of Research, Weill Cornell Medicine-Qatar of Cornell University, Doha, Qatar.
Pooja GeorgeNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Ali Ulvi UcaDepartment of Neurology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Ahmet OzkagniciDepartment of Neurology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Faiza IbrahimNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Reny FrancisNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Beatriz CanibanoNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Dirk DeleuNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Ahmed El-SotouhyNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Surjith VattothNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Ahmed OwnNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Ashfaq ShuaibNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Naveed AkhtarNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.
Saadat KamranNeuroscience Institute, Hamad Medical Corporation, Doha, Qatar.ORCID https://orcid.org/0000-0002-0260-2086
Rayaz A MalikDivision of Research, Weill Cornell Medicine-Qatar, Cornell University and Qatar Foundation, Education City, PO Box 24144, Doha, Qatar.ORCID https://orcid.org/0000-0002-7188-8903

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Resourceful endpoints of axonal loss are needed to predict the course of multiple sclerosis (MS). Corneal confocal microscopy (CCM) can detect axonal loss in patients with clinically isolated syndrome and established MS, which relates to neurological disability. Objective: To assess corneal axonal loss over time in relation to retinal atrophy, and neurological and radiological abnormalities in MS. Methods: Patients with relapsing-remitting (RRMS) ( Results: In patients with RRMS compared with controls at baseline, CNFD ( Conclusion: Progressive corneal and retinal axonal loss was identified in patients with MS, especially those with more active disease. CCM may serve as an imaging biomarker of axonal loss in MS.

Indexed as

axonal lossbiomarkercorneal confocal microscopymultiple sclerosisneurodegeneration

Identifiers

PMID36776530
PMCPMC9909084

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.