ArticleLancet regional health. Americas2022
Organization of cervical cancer screening with DNA-HPV testing impact on early-stage cancer detection: a population-based demonstration study in a Brazilian city.
Article in Lancet regional health. Americas, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cervical cancer screening policy inequality worldwide: a systematic review of disparities in access and implementation.Journal of translational medicine · 2026Pooled it
- Clinical Considerations on HPV Knowledge, Screening, and Vaccination in Brazilian Primary Care: Letter to the Editor.Health science reports · 2026Article
- High-risk oncogenic HPV genotypes in vulnerable women from the Amazon: a cross-sectional retrospective study.Virology journal · 2026Article
- High Burden ofMicroorganisms · 2026Article
- Cost-utility of screening with liquid cytology or p16/Ki67 dual stain in women identified in cervical cancer triage with non 16/18 HR-HPV.International journal of technology assessment in health care · 2026Article
- Evaluation and Recommendations to Modernize Cervical Cancer Detection and Prevention Programs in Brazil: Challenges and Opportunities - A Narrative Review.Acta cytologica · 2026Review
- Incidence and survival of vulvar and vaginal cancers in a province of Northern Italy: a population-based study.Gynecologic oncology reports · 2025Article
- Trends in net survival from cervical cancer in a Brazilian state with medium Human Development Index.Scientific reports · 2025Article
- Barriers of organized cervical cancer screening in Albania and Montenegro.BMC public health · 2025Article
- Standardization of a Molecular Technique for Human Papillomavirus Genotyping in a Public-Health Service.Cureus · 2025Article
- Transition from opportunistic cytological to organized screening program with DNA-HPV testing detected prevalent cervical cancers 10 years in advance.Scientific reports · 2024Article
- Population-level cancer screening and cancer care in Bhutan, 2020-2023: a review.The Lancet regional health. Southeast Asia · 2024Review
- Risk Profile of High-grade Cervical Lesions and Cervical Cancer Considering the Combination of Cytology, HPV Genotype, and Age among Women Undergoing Colposcopy.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Article
- Papanicolaou test in Brazil: analysis of the National Health Survey of 2013 and 2019.Revista de saude publica · 2023Article
- Cervical Cancer Screening with DNA-HPV Testing and Precancerous Lesions Detection: A Brazilian Population-based Demonstration Study.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- A promising technique to improve and expand the practice of colposcopy to help the global fight against cervical cancer.Annals of translational medicine · 2022Article
- Implementation of HPV Tests in Latin America: What We Learned; What Should We Have Learned, and What Can We Do Better?Cancers · 2022Review
- Cervical Lesion Classification Method Based on Cross-Validation Decision Fusion Method of Vision Transformer and DenseNet.Journal of healthcare engineering · 2022Article
- Cervical cancer screening, treatment and prophylaxis in Brazil: Current and future perspectives for cervical cancer elimination.Frontiers in medicine · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cervical cancer is a preventable disease, and the Brazilian screening is opportunistic and has low impact. The current study evaluated an initiative to organize screening using DNA-HPV testing as a replacement for cytology. Methods: This demonstration study examined information from 16 384 DNA-HPV tests for screening in women aged 25-64 years from Indaiatuba city between October 2017-March 2020. The comparison was 20 284 women screened using cytology between October 2014-March 2017. The flowchart indicates the repetition of a negative test in five years. HPV16- and/or HPV18-positive tests and the 12 pooled high-risk HPV-positive tests with abnormal liquid-based cytology were referred for colposcopy. If cytology was negative, the HPV test was repeated in 12 months. The analyses evaluated coverage, age-group compliance, and cancer detected. Findings: After 30 months, the coverage projection was greater than 80%. The age compliance for the HPV test was 99.25%, compared to 78.0% in the cytology program. The HPV test program showed 86.8% negative tests and 6.3% colposcopy referrals, with 78% colposcopies performed. The HPV testing program detected 21 women with cervical cancer with a mean age of 39.6 years, and 67% of cancers were early-stage compared to 12 cervical cancer cases detected by cytological screening (p=0.0284) with a mean age of 49.3 years (p=0.0158), and one case of early-stage (p=0.0014). Interpretation: Organizing cervical cancer screening using DNA-HPV testing demonstrated high coverage and age compliance in a real-life scenario, and it had an immediate impact on cervical cancer detection at an early-stage. Funding: University of Campinas, Indaiatuba City, and Roche Diagnostics.
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