Evidence map›Paper›PMID 36776074›Full record

ArticleJournal of Alzheimer's disease : JAD2023

Mortality Risks and Causes of Death by Dementia Types in a Japanese Cohort with Dementia: NCGG-STORIES.

Rei Ono, Takashi Sakurai, Taiki Sugimoto, Kazuaki Uchida, Takeshi Nakagawa, Taiji Noguchi, Ayane Komatsu, Hidenori Arai, Tami Saito

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Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Dementia and all-cause mortality in older adults: Findings from the ELSI-Brazil study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  5. Cognitive trajectories in older adults and associated mortality and predictors.Social psychiatry and psychiatric epidemiology · 2025
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  10. Observational
  11. Different cohort, disparate results: Selection bias is a key factor in autopsy cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rei OnoDepartment of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
Takashi SakuraiCenter for Comprehensive Care and Research on Memory Disorders, Hospital, National Center for Geriatrics and Gerontology, Aichi, Japan.
Taiki SugimotoCenter for Comprehensive Care and Research on Memory Disorders, Hospital, National Center for Geriatrics and Gerontology, Aichi, Japan.
Kazuaki UchidaCenter for Comprehensive Care and Research on Memory Disorders, Hospital, National Center for Geriatrics and Gerontology, Aichi, Japan.
Takeshi NakagawaDepartment of Social Science, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.
Taiji NoguchiDepartment of Social Science, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.
Ayane KomatsuDepartment of Social Science, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.
Hidenori AraiNational Center for Geriatrics and Gerontology, Aichi, Japan.
Tami SaitoDepartment of Social Science, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrognosis-related information regarding dementia needs to be updated, as changes in medical and long-term care environments for patients with dementia in recent decades may be improving the prognosis of the disease.

objectiveWe aimed to investigate the mortality, cause of death, and prognostic factors by types of dementia in a Japanese clinic-based cohort.

methodsThe National Center for Geriatrics and Gerontology-Life Stories of People with Dementia consists of clinical records and prognostic data of patients who visited the Memory Clinic in Japan. Patients who attended the clinic between July 2010 and September 2018, or their close relatives, were asked about death information via a postal survey. A cohort of 3,229 patients (mean age, 76.9; female, 1,953) was classified into six groups: normal cognition (NC), mild cognitive impairment (MCI), Alzheimer's disease (AD), vascular dementia, dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration. A Cox proportional hazards model was employed to compare the mortality of each type of dementia, MCI, and NC.

resultsPatients with all types of dementia and MCI had higher mortality rates than those with NC (hazard risks: 2.61-5.20). The most common cause of death was pneumonia, followed by cancer. In the MCI, AD, and DLB groups, older age, male sex, and low cognitive function were common prognostic factors but not presence of apolipoprotein E ɛ4 allele.

conclusionOur findings suggest important differences in the mortality risk and cause of death among patients with dementia, which will be useful in advanced care planning and policymaking.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDementiaLewy Body DiseaseAgedCause of DeathEast Asian PeopleFemaleHumansMaleAlzheimer’s diseasecause of deathfrontotemporal lobar degenerationLewy bodiesmild cognitive impairmentmortalityprognostic factorvascular dementia

Identifiers

PMID36776074
PMCPMC10041427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.