Evidence map›Paper›PMID 36775672›Full record

ArticleThe Journal of nutrition2023

Physical activity and diet associations with the gut microbiota in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Aylin Memili, Anju Lulla, Hongwei Liu, James M Shikany, David R Jacobs, Lisa Langsetmo, Kari E North, Corbin Jones, Lenore J Launer, Katie A Meyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Aylin MemiliDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anju LullaNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Hongwei LiuDepartments of Biology, iBGS, and Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
James M ShikanyDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
David R JacobsDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Lisa LangsetmoDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA; Center for Care Delivery and Outcomes Research, VA Health Care System, Minneapolis, MN, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Corbin JonesDepartments of Biology, iBGS, and Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lenore J LaunerNational Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Katie A MeyerDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. Electronic address: ktmeyer@unc.edu.
University of North Carolina at Chapel Hill · USUniversity of Minnesota · USNational Institutes of Health · USUniversity of Alabama at Birmingham · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9M
A Novel Gut Microbial-Dependent Nutrient Metabolite and AtherosclerosisK01HL127159 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEYER, KATIE A · 2015 to 2019
$787k
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS K01 HL127159NHLBI NIH HHS R01 HL143885NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

backgroundGut microbiota may influence metabolic pathways related to chronic health conditions. Evidence for physical activity and diet influences on gut microbial composition exists, but data from diverse population-based cohort studies are limited.

objectivesWe hypothesized that gut microbial diversity and genera are associated with physical activity and diet quality.

methodsData were from 537 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a prospective cohort, who attended the year 30 follow-up examination (2015-2016; aged 47-61 y; 45% Black race/55% White race; 45% men/55% women). The 16S ribosomal RNA marker gene was sequenced from stool DNA, and genus-level taxonomy was assigned. Within-person microbial diversity (α-diversity) was assessed with Shannon diversity index and richness scores; between-person diversity (β-diversity) measures were generated with principal coordinates analysis (PCoA). Current and long-term physical activity and diet quality measures were derived from data collected over 30 y of follow-up. Multivariable-adjusted regression analysis controlled for: sociodemographic variables (age, race, sex, education, and field center), other health behaviors (smoking, alcohol consumption, and medication use), and adjusted for multiple comparisons with the false discovery rate (<0.20).

resultsBased on PCoA β-diversity, participants' microbial community compositions differed significantly (P < 0.001), with respect to both current and long-term physical activity and diet quality. α-Diversity was associated only with current physical activity (positively) in multivariable-adjusted analysis. Multiple genera (n = 45) were associated with physical activity and fewer with diet (n = 5), including positive associations with Lachnospiraceae UCG-001 and Ruminococcaceae IncertaeSedis with both behaviors.

conclusionsPhysical activity and diet quality were associated with gut microbial composition among 537 participants in the CARDIA study. Multiple genera were associated with physical activity. Physical activity and diet quality were associated with genera consistent with pathways related to inflammation and short-chain fatty acid production.

Indexed as

Gastrointestinal MicrobiomeCoronary VesselsDietExerciseFecesFemaleHumansMaleProspective StudiesRNA, Ribosomal, 16SYoung AdultRNA, Ribosomal, 16Scohortdietepidemiologygut microbiotahealth behaviorsmicrobiomephysical activity

Identifiers

PMID36775672
PMCPMC10127529
OpenAlexW4312220254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.