Evidence map›Paper›PMID 36775256›Full record

ArticleInternational journal of antimicrobial agents2023

Nafcillin Augmentation of Daptomycin and Cathelicidin LL-37 Killing of Methicillin-resistant Staphylococcus epidermidis: Foundations of Successful Therapy of Endocarditis.

Lucy Catteau, Yvan Diaz Iglesias, Hannah Tsunemoto, Joseph Pogliano, Françoise Van Bambeke, Victor Nizet, George Sakoulas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of antimicrobial agents, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. The Evolution of Symbiosis inBiomolecules · 2026
    Review
  2. Active components ofFrontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lucy CatteauUniversity of California San Diego School of Medicine, La Jolla, CA; Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Yvan Diaz IglesiasLouvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Hannah TsunemotoDepartment of Biological Sciences, University of California San Diego, La Jolla, CA.
Joseph PoglianoDepartment of Biological Sciences, University of California San Diego, La Jolla, CA.
Françoise Van BambekeLouvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Victor NizetUniversity of California San Diego School of Medicine, La Jolla, CA; Skaggs School of Pharmacy, University of California San Diego, La Jolla, CA.
George SakoulasUniversity of California San Diego School of Medicine, La Jolla, CA; Sharp Rees Stealy Medical Group, San Diego, CA. Electronic address: gsakoulas@health.ucsd.edu.
University of California San Diego · USUCLouvain · BE

Funding

Safety and Dose Optimization of High-Dose Anakinra in Kawasaki DiseaseU54HD090259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIGAM, SANJAY K · 2016 to 2018
$2.2M
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9M
NIAID NIH HHS R01 AI145310NICHD NIH HHS U54 HD090259
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus epidermidis (MRSE) endocarditis failing conventional therapy has been successfully treated with nafcillin plus daptomycin in the clinic. In vitro studies showed that nafcillin enhanced daptomycin killing of MRSE in both planktonic cells and biofilm. Nafcillin exposure also sensitized MRSE to killing by human neutrophils and cathelicidin antimicrobial peptide LL-37. Fluorescent microscopy showed increased daptomycin and LL-37 binding to the MRSE bacterial surface upon nafcillin treatment. Ceftaroline also increased MRSE killing by daptomycin in planktonic cultures and biofilms, as well as daptomycin and LL-37 binding on the bacterial surface. Nafcillin, ceftaroline, and possibly other β-lactams, may serve an important role in the therapy of MRSE endocarditis through augmentation of cationic peptide, the innate immune system, and daptomycin killing. Clinical studies will be needed to determine how early these regimens should be deployed to optimize clinical outcome.

Indexed as

DaptomycinEndocarditisMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsCathelicidinsCeftarolineHumansMethicillin ResistanceMicrobial Sensitivity TestsNafcillinStaphylococcus epidermidisAnti-Bacterial AgentsCathelicidinsCeftarolineDaptomycinNafcillinantimicrobial peptidecathelicidincombination therapydaptomycinendocarditismethicillin-resistant Staphylococcus epidermidisnafcillin

Identifiers

PMID36775256
PMCPMC10334303
OpenAlexW4319875148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.