Evidence map›Paper›PMID 36775127›Full record

ArticleThe Journal of biological chemistry2023

The Pseudomonas aeruginosa PAO1 metallo flavoprotein d-2-hydroxyglutarate dehydrogenase requires Zn

Joanna A Quaye, Giovanni Gadda

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Substitution of ZnACS omega · 2025
    Article
  2. Article
  3. Characterization of a Periplasmic D-Malate:CytochromeInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Uncovering ZnThe Journal of biological chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joanna A QuayeDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA.
Giovanni GaddaDepartment of Chemistry, Georgia State University, Atlanta, Georgia, USA; Department of Biology, Georgia State University, Atlanta, Georgia, USA; Department of The Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, USA. Electronic address: ggadda@gsu.edu.
Georgia State University · US

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Pseudomonas aeruginosa PAO1 d-2-hydroxyglutarate (D2HG) dehydrogenase (PaD2HGDH) oxidizes D2HG to 2-ketoglutarate during the vital l-serine biosynthesis and is a potential therapeutic target against P. aeruginosa. PaD2HGDH, which oxidizes d-malate as an alternative substrate, has been demonstrated to be a metallo flavoprotein that requires Zn

Indexed as

MalatesPseudomonas aeruginosaAlcohol OxidoreductasesCatalysisFlavinsFlavoproteinsKineticsOxidation-ReductionSubstrate SpecificityZinc2-hydroxyglutarate dehydrogenaseAlcohol OxidoreductasesFlavinsFlavoproteinsMalatesmalic acidZinccatalytic mechanismD-2-hydroxyglutarated-malateflavinmetallo flavoproteinPseudomonas aeruginosa D-2-hydroxyglutarate dehydrogenasereductive-half reactionZn(2+)

Identifiers

PMID36775127
PMCPMC10034468
OpenAlexW4319868839

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read70
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.