Evidence map›Paper›PMID 36774552›Full record

ArticleCell reports2023

Regional and cell-type-specific afferent and efferent projections of the mouse claustrum.

Quanxin Wang, Yun Wang, Hsien-Chi Kuo, Peng Xie, Xiuli Kuang, Karla E Hirokawa, Maitham Naeemi, Shenqin Yao, Matt Mallory, Ben Ouellette and 12 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
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  3. Review
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  7. Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026
    Article
  8. Nurr1 Orchestrates Claustrum Development and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Specific Glutamatergic Projection to Claustrum for Regulating Methamphetamine Abstinence Anxiety-Like Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Quanxin WangAllen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: quanxinw@alleninstitute.org.
Yun WangAllen Institute for Brain Science, Seattle, WA 98109, USA.
Hsien-Chi KuoAllen Institute for Brain Science, Seattle, WA 98109, USA.
Peng XieInstitute for Brain and Intelligence, Southeast University, Nanjing, Jiangsu, China.
Xiuli KuangSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Karla E HirokawaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Maitham NaeemiAllen Institute for Brain Science, Seattle, WA 98109, USA.
Shenqin YaoAllen Institute for Brain Science, Seattle, WA 98109, USA.
Matt MalloryAllen Institute for Brain Science, Seattle, WA 98109, USA.
Ben OuelletteAllen Institute for Brain Science, Seattle, WA 98109, USA.
Phil LesnarAllen Institute for Brain Science, Seattle, WA 98109, USA.
Yaoyao LiSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Min YeSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Chao ChenSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Wei XiongSchool of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Leila AhmadiniaAllen Institute for Brain Science, Seattle, WA 98109, USA.
Laila El-HifnawiAllen Institute for Brain Science, Seattle, WA 98109, USA.
Ali CetinAllen Institute for Brain Science, Seattle, WA 98109, USA.
Staci A SorensenAllen Institute for Brain Science, Seattle, WA 98109, USA.
Julie A HarrisAllen Institute for Brain Science, Seattle, WA 98109, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA 98109, USA.
Christof KochAllen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: christofk@alleninstitute.org.
Allen Institute for Brain Science · USWenzhou Medical University · CNSoutheast University · CN

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and subcortical regions. Its regional anatomy and cell-type-specific connections in the mouse remain not fully determined. Using multimodal reference datasets, we confirmed the delineation of the mouse CLA as a single group of neurons embedded in the agranular insular cortex. We quantitatively investigated brain-wide inputs and outputs of CLA using bulk anterograde and retrograde viral tracing data and single neuron tracing data. We found that the prefrontal module has more cell types projecting to the CLA than other cortical modules, with layer 5 IT neurons predominating. We found nine morphological types of CLA principal neurons that topographically innervate functionally linked cortical targets, preferentially the midline cortical areas, secondary motor area, and entorhinal area. Together, this study provides a detailed wiring diagram of the cell-type-specific connections of the mouse CLA, laying a foundation for studying its functions at the cellular level.

Indexed as

ClaustrumMotor CortexAnimalsEntorhinal CortexMiceNeural PathwaysNeuronsAAVanterograde tracingcell typeclaustrumCP: Neuroscienceisocortexmouserabies virusretrograde tracingsingle neuron reconstruction

Identifiers

PMID36774552
PMCPMC10415534
OpenAlexW4320167841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.