Evidence map›Paper›PMID 36774489›Full record

ArticleMolecular brain2023

The deficiency of Maged1 attenuates Parkinson's disease progression in mice.

Jie Wang, Sheng-Ye Xu, Zhi-Yuan Ye, Zhou-Na Sun, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Chuan He, Wei-Yan You and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jie Wang *Department of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Sheng-Ye Xu *Department of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Zhi-Yuan YeDepartment of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Zhou-Na SunDepartment of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Jia-Qi ZhangDepartment of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Cui QiDepartment of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Rui LiuDepartment of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
Xiang GaoSKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, 210061, China.
Chuan HeDepartment of Rehabilitation Medicine, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China. he-chuan@outlook.com.
Wei-Yan YouDepartment of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. youweiyan@njmu.edu.cn.
Jun GaoDepartment of Neurobiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. gaojun@njmu.edu.cn.ORCID http://orcid.org/0000-0002-5925-537X
Nanjing Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNModel Animal Research Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma-associated antigen D1 (Maged1) has critical functions in the central nervous system in both developmental and adult stages. Loss of Maged1 in mice has been linked to depression, cognitive disorder, and drug addiction. However, the role of Maged1 in Parkinson's disease (PD) remains unclear. In this study, we observed that Maged1 was expressed in the dopaminergic (DA) neurons of the substantia nigra in mice and humans, which could be upregulated by the in vivo or in vitro treatment with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 1-Methyl-4-phenylpyridinium iodide (MPP

Indexed as

Neoplasm ProteinsParkinson Disease1-Methyl-4-phenylpyridiniumAnimalsDisease Models, AnimalDisease ProgressionDopaminergic NeuronsHumansMiceMice, Inbred C57BLSignal Transduction1-Methyl-4-phenylpyridiniumMaged1 protein, mouseNeoplasm ProteinsApoptosisAutophagyMelanoma-associated antigen D1Parkinson’s diseaseSubstantia nigra

Identifiers

PMID36774489
PMCPMC9921624
OpenAlexW4320037902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.