Evidence map›Paper›PMID 36774432›Full record

ArticleBone marrow transplantation2023

HLA-haploidentical hematopoietic stem cells transplantation with regulatory and conventional T-cell adoptive immunotherapy in pediatric patients with very high-risk acute leukemia.

M S Massei, I Capolsini, E Mastrodicasa, K Perruccio, F Arcioni, C Cerri, G Gurdo, S Sciabolacci, F Falzetti, T Zei and 15 more

Open access · bronzeAbstract read
In one paragraph

Article in Bone marrow transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Haematologica · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Haploidentical HSCT in the Treatment of Pediatric Hematological Disorders.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 3 institutions in 1 country.

M S MasseiPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy. msperanza.massei@ospedale.perugia.it.ORCID 0000-0002-8954-6098
I CapolsiniPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
E MastrodicasaPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
K PerruccioPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.ORCID 0000-0003-0431-3197
F ArcioniPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
C CerriPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
G GurdoPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
S SciabolacciPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
F FalzettiDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
T ZeiDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
R Iacucci OstiniDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
M BrognaPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
B M PanizzaRadiation Oncology Section, Santa Maria della Misericordia Hospital, Perugia, Italy.
S SaldiRadiation Oncology Section, Santa Maria della Misericordia Hospital, Perugia, Italy.
M MerluzziDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
R TognelliniImmunohaematology, Transfusion Service and Apheresis, Santa Maria della Misericordia Hospital, Perugia, Italy.
M MarchesiImmunohaematology, Transfusion Service and Apheresis, Santa Maria della Misericordia Hospital, Perugia, Italy.
O MinelliImmunohaematology, Transfusion Service and Apheresis, Santa Maria della Misericordia Hospital, Perugia, Italy.
C AristeiRadiation Oncology Section, Santa Maria della Misericordia Hospital, Perugia, Italy.
A VelardiDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
A PieriniDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
L RuggeriDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID 0000-0002-3804-2551
M F MartelliDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
A CarottiDivision of Hematology and Clinical Immunology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
M CanigliaPediatric Oncology-Hematology Unit, Santa Maria della Misericordia Hospital, Perugia, Italy.
Ospedale Santa Maria · ITUniversity of Perugia · ITAzienda Ospedaliera di Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is still needed for many children with very high-risk acute leukemia. An HLA-haploidentical family donor is a suitable option for those without an HLA-matched donor. Here we present outcomes of a novel HLA-haploidentical HSCT (haplo-HSCT) strategy with adoptive immunotherapy with thymic-derived CD4

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteAdolescentChildHematopoietic Stem CellsHumansImmunotherapy, AdoptiveTransplantation Conditioning

Identifiers

PMID36774432
PMCPMC9919737
OpenAlexW4320039705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.