Evidence map›Paper›PMID 36774427›Full record

ArticleAnnals of biomedical engineering2024

PEG-Based Hydrogel Coatings: Design Tools for Biomedical Applications.

Megan Wancura, Abbey Nkansah, Andrew Robinson, Shireen Toubbeh, Michael Talanker, Sarah Jones, Elizabeth Cosgriff-Hernandez

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Design of PEG-Based Hydrogels as Soft Ionic Conductors.Journal of biomedical materials research. Part A · 2025
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megan WancuraDepartment of Chemistry, The University of Texas at Austin, Austin, TX, 78712, USA.
Abbey NkansahDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Andrew RobinsonDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Shireen ToubbehDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Michael TalankerDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Sarah JonesDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Elizabeth Cosgriff-HernandezDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA. cosgriff.hernandez@utexas.edu.ORCID http://orcid.org/0000-0002-4701-5600

Funding

EFFECT OF IMPROVED GRAFT COMPLIANCE MATCHING ON INTIMAL HYPERPLASIAR21EB020978 · NIBIB · TEXAS ENGINEERING EXPERIMENT STATION · PI MAITLAND, DUNCAN J · 2015 to 2016
$362k
NIH HHS R21 EB020978
6 · The paper itself

Abstract

Device failure due to undesired biological responses remains a substantial roadblock in the development and translation of new devices into clinical care. Polyethylene glycol (PEG)-based hydrogel coatings can be used to confer antifouling properties to medical devices-enabling minimization of biological responses such as bacterial infection, thrombosis, and foreign body reactions. Application of hydrogel coatings to diverse substrates requires careful consideration of multiple material factors. Herein, we report a systematic investigation of two coating methods: (1) traditional photoinitiated hydrogel coatings; (2) diffusion-mediated, redox-initiated hydrogel coatings. The effects of method, substrate, and compositional variables on the resulting hydrogel coating thickness are presented. To expand the redox-based method to include high molecular weight macromers, a mechanistic investigation of the role of cure rate and macromer viscosity was necessary to balance solution infiltration and gelation. Overall, these structure-property relationships provide users with a toolbox for hydrogel coating design for a broad range of medical devices.

Indexed as

Coated Materials, BiocompatibleHydrogelsPolyethylene GlycolsHumansCoated Materials, BiocompatibleHydrogelsPolyethylene GlycolsHydrogel coatingsPhotoinitiationPoly(ethylene glycol) hydrogelsRedox initiation

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.