ArticleCommunications medicine2023
Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT.
Article in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Virtual left atrial appendage occlusion in paroxysmal atrial fibrillation during sinus rhythm predicts variable reductions in blood stasis.The Journal of physiology · 2026Article
- Velocimetry based on multiphase CCTA images for reliable coronary flow velocity quantification across stenosis severities and ischemia detection.Medical physics · 2026Article
- Poor Distal Left Atrial Appendage Opacification on Early-Phase Cardiac CTA and Association With Arterial Thromboembolism.Reviews in cardiovascular medicine · 2026Article
- Article
- CFD-derived radiomics from hemodynamic maps for quantitative assessment of left atrial flow in atrial fibrillation: a proof-of-concept study.Frontiers in cardiovascular medicine · 2026Article
- Accurate fully automated assessment of left ventricle, left atrium, and left atrial appendage function from computed tomography using deep learning.European heart journal. Imaging methods and practice · 2024Article
- Impact of occluder device configurations in in-silico left atrial hemodynamics for the analysis of device-related thrombus.PLoS computational biology · 2024Article
- Comprehensive left atrial flow component analysis reveals abnormal flow patterns in paroxysmal atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2024Article
- Mechanisms and Prediction of Ischemic Stroke in Atrial Fibrillation Patients.Journal of clinical medicine · 2023Review
- Assessment of transmitral and left atrial appendage flow rate from cardiac 4D-CT.Communications medicine · 2023Article
- Elevated atrial blood stasis in paroxysmal atrial fibrillation during sinus rhythm: a patient-specific computational fluid dynamics study.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundCardiac time-resolved CT (4D-CT) acquisitions provide high quality anatomical images of the heart. However, some cardiac diseases require assessment of blood flow in the heart. Diastolic dysfunction, for instance, is diagnosed by measuring the flow through the mitral valve (MV), while in atrial fibrillation, the flow through the left atrial appendage (LAA) indicates the risk for thrombus formation. Accurate validated techniques to extract this information from 4D-CT have been lacking, however.
methodsTo measure the flow rate though the MV and the LAA from 4D-CT, we developed a motion tracking algorithm that performs a nonrigid deformation of the surface separating the blood pool from the myocardium. To improve the tracking of the LAA, this region was deformed separately from the left atrium and left ventricle. We compared the CT based flow with 4D flow and short axis MRI data from the same individual in 9 patients.
resultsFor the mitral valve flow, good agreement was found for the time span between the early and late diastolic peak flow (bias: <0.1 s). The ventricular stroke volume is similar compared to short-axis MRI (bias 3 ml). There are larger differences in the diastolic peak flow rates, with a larger bias for the early flow rate than the late flow rate. The peak LAA outflow rate measured with both modalities matches well (bias: -6 ml/s).
conclusionsOverall, the developed algorithm provides accurate tracking of dynamic cardiac geometries resulting in similar flow rates at the MV and LAA compared to 4D flow MRI.
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Registered trials
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