ArticleNPJ systems biology and applications2023
Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms.
Article in NPJ systems biology and applications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Changing temporal patterns in patient-reported wish to live and wish to die signal the imminent emergence and aftermath of suicide attempts: a dynamical systems analysis.BMC psychiatry · 2025Trial
- Waveform distortion for temperature compensation and synchronization in circadian rhythms: An approach based on the renormalization group method.PLoS computational biology · 2025Article
- Positioning of negative feedback loops within immune signaling pathways influences gene expression noise.bioRxiv : the preprint server for biology · 2025Article
- When lowering temperature, the in vivo circadian clock in cyanobacteria follows and surpasses the in vitro protein clock trough the Hopf bifurcation.Scientific reports · 2025Article
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Oscillatory autophagy induction is enabled by an updated AMPK-ULK1 regulatory wiring.PloS one · 2024Article
- A synthetic population-level oscillator in non-microfluidic environments.Communications biology · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Temperature compensation and robustness to biological noise are two key characteristics of the circadian clock. These features allow the circadian pacemaker to maintain a steady oscillation in a wide range of environmental conditions. The presence of a time-delayed negative feedback loop in the regulatory network generates autonomous circadian oscillations in eukaryotic systems. In comparison, the circadian clock of cyanobacteria is controlled by a strong positive feedback loop. Positive feedback loops with substrate depletion can also generate oscillations, inspiring other circadian clock models. What makes a circadian oscillatory network robust to extrinsic noise is unclear. We investigated four basic circadian oscillators with negative, positive, and combinations of positive and negative feedback loops to explore network features necessary for circadian clock resilience. We discovered that the negative feedback loop system performs the best in compensating temperature changes. We also show that a positive feedback loop can reduce extrinsic noise in periods of circadian oscillators, while intrinsic noise is reduced by negative feedback loops.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.