Evidence map›Paper›PMID 36773980›Full record

ArticleSaudi medical journal2023

Does the preoperative fasting period affect the liver in a distant organ model of renal ischaemia reperfusion?

Yasemin Akcaalan, Ersin Gurkan Dumlu, Ebru Menekse, Mustafa Cem Yilmaz, Ezgi Erkilic, Betul Ogut, Aylin Sepıcı Dıncel

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Article in Saudi medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yasemin AkcaalanFrom the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.
Ersin Gurkan DumluFrom the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.
Ebru MenekseFrom the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.
Mustafa Cem YilmazFrom the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.
Ezgi ErkilicFrom the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.
Betul OgutFrom the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.
Aylin Sepıcı DıncelFrom the Department of Anesthesia and Reanimation (Akcaalan, Yilmaz, Erkilic), Ankara City Hospital, from the Department of General Surgery (Dumlu, Menekse), Ankara Yıldırım Beyazıt University, from the Department of Pathology (Ogut); and from the Department of Biochemistry (Dıncel), Medicine Faculty, Ankara Gazi University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo experimentally evaluate the effects of preoperative fasting duration on distant organ liver in renal ischaemia-reperfusion (IR) injury.

methodsThis is an experimental study. In the study, 3 groups were formed. In Group A, abdominal laparotomy was carried out after 12 hours of preoperative fasting without any IR damage. In Group B, IR injury was carried out after 12 hours of preoperative fasting, and abdominal laparotomy was carried out, in Group C after 2 hours of fasting after IR injury. Apoptosis, congestion, balloon degeneration, nuclear pleomorphism, and leukocyte infiltration were examined histopathologically and tumor necrosis factor-alpha (TNF-α), interleukin (IL) -1 beta, IL-6, and IL-10 were evaluated biochemically.

resultsA statistically significant difference was determined between the groups in respect of postoperative IL-10 levels (

conclusionWith this result, it would be correct to say that the short preoperative fasting period has protective effects on the liver tissue.

Indexed as

Acute Kidney InjuryReperfusion InjuryFastingHumansInterleukin-10IschemiaLiverReperfusionTumor Necrosis Factor-alphaInterleukin-10Tumor Necrosis Factor-alphaERASischaemia reperfusionpreoperative fasting

Identifiers

PMID36773980
PMCPMC9987707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.