Evidence map›Paper›PMID 36773825›Full record

ReviewRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2023

Applicability and usage of dose mapping/accumulation in radiotherapy.

Martina Murr, Kristy K Brock, Marco Fusella, Nicholas Hardcastle, Mohammad Hussein, Michael G Jameson, Isak Wahlstedt, Johnson Yuen, Jamie R McClelland, Eliana Vasquez Osorio

Abstract readReview
In one paragraph

Review in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Review
  2. First dosimetric evaluation of deformable dose accumulation in human individuals.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  3. Article
  4. Modeling Time-Dependent Recovery to Improve Esophagitis Prediction in Thoracic Reirradiation.International journal of radiation oncology, biology, physics · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A reirradiation workflow for managing patients with treatments planned in a multi-TPS environment.Technical innovations & patient support in radiation oncology · 2026
    Article
  12. Article
  13. A dedicated institutional clinical workflow and peer-review meeting for reirradiation.Technical innovations & patient support in radiation oncology · 2026
    Article
  14. Article
  15. Accuracy of reirradiation dose constraints for the mandible and carotids.Physics and imaging in radiation oncology · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martina MurrSection for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Germany. Electronic address: Martina.Murr@med.uni-tuebingen.de.
Kristy K BrockDepartment of Imaging Physics and Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, USA.
Marco FusellaDepartment of Radiation Oncology, Abano Terme Hospital, Italy.
Nicholas HardcastlePhysical Sciences, Peter MacCallum Cancer Centre & Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia.
Mohammad HusseinMetrology for Medical Physics Centre, National Physical Laboratory, Teddington, United Kingdom.
Michael G JamesonGenesisCare New South Wales, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Australia.
Isak WahlstedtDepartment of Health Technology, Technical University of Denmark, Anker Engelunds Vej 1, Bygning 101A, 2800 Kongens Lyngby, Denmark; Department of Oncology, Centre for Cancer and Organ Diseases, Copenhagen University Hospital - Rigshospitalet (RH), Blegdamsvej 9, 2100 Copenhagen, Denmark; Department of Oncology, Copenhagen University Hospital - Herlev and Gentofte (HGH), Borgmester Ib Juuls Vej 7, 2730 Herlev, Denmark.
Johnson YuenSt George Hospital Cancer Care Centre, Kogarah, NSW 2217, Australia; South Western Clinical School, University of New South Wales, Sydney, Australia; Ingham Institute for Applied Medical Research, Sydney, NSW, Australia.
Jamie R McClellandCentre for Medical Image Computing and Wellcome/EPSRC Centre for Interventional and Surgical Sciences, Dept of Medical Physics and Biomedical Engineering, UCL, United Kingdom.
Eliana Vasquez OsorioDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, M20 4BX Manchester, United Kingdom.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.P01CA261669 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HONG, THEODORE S · 2021 to 2025
$14.0M
Optimization and Evaluation of Anatomical Models of Liver Radiation ResponseR01CA221971 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BROCK, KRISTY · 2018 to 2022
$1.8M
Cancer Research UK 21993Cancer Research UK 28701Cancer Research UK A21993Cancer Research UK C1994/A28701NCI NIH HHS P01 CA261669NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA221971Wellcome TrustWellcome Trust 203145/Z/16/Z
6 · The paper itself

Abstract

Dose mapping/accumulation (DMA) is a topic in radiotherapy (RT) for years, but has not yet found its widespread way into clinical RT routine. During the ESTRO Physics workshop 2021 on "commissioning and quality assurance of deformable image registration (DIR) for current and future RT applications", we built a working group on DMA from which we present the results of our discussions in this article. Our aim in this manuscript is to shed light on the current situation of DMA in RT and to highlight the issues that hinder consciously integrating it into clinical RT routine. As a first outcome of our discussions, we present a scheme where representative RT use cases are positioned, considering expected anatomical variations and the impact of dose mapping uncertainties on patient safety, which we have named the DMA landscape (DMAL). This tool is useful for future reference when DMA applications get closer to clinical day-to-day use. Secondly, we discussed current challenges, lightly touching on first-order effects (related to the impact of DIR uncertainties in dose mapping), and focusing in detail on second-order effects often dismissed in the current literature (as resampling and interpolation, quality assurance considerations, and radiobiological issues). Finally, we developed recommendations, and guidelines for vendors and users. Our main point include: Strive for context-driven DIR (by considering their impact on clinical decisions/judgements) rather than perfect DIR; be conscious of the limitations of the implemented DIR algorithm; and consider when dose mapping (with properly quantified uncertainties) is a better alternative than no mapping.

Indexed as

Radiation OncologyAlgorithmsHumansImage Processing, Computer-AssistedRadiotherapy DosageRadiotherapy Planning, Computer-AssistedAnatomical changesDeformable image registration (DIR)DIR uncertaintiesDose mapping/accumulationDose mapping/accumulation landscape (DMAL)Impact of dose mapping uncertainties

Identifiers

PMID36773825
PMCPMC11877414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.