ReviewNeuropharmacology2023
Orchestration of innate and conditioned defensive actions by the periaqueductal gray.
Review in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- PAG-dependent defensive strategy selection: From stress-induced rigidity to adaptive flexibility.iScience · 2026Article
- Brain-Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus.CNS neuroscience & therapeutics · 2026Article
- Efferent projections of topographically distinct relaxin family peptide receptor-3 (RXFP3) lateral hypothalamus/zona incerta cells.Brain structure & function · 2026Article
- The neuroanatomy and connectivity of the ventral striatum and ventral capsule area in the Göttingen minipig.Brain structure & function · 2026Article
- Prenatal Alcohol Exposure: Impact on Neuroimmune Function in the Stress Response and Pain.Advances in experimental medicine and biology · 2026Review
- Fleeing is believing: adaptive behavior under social threat as an inference process.Frontiers in neural circuits · 2026Article
- A novel role for the infralimbic cortex in conditioned fear responding.Oxford open neuroscience · 2026Article
- Brain-Wide Patterns of CRF Receptor 1 Expression in the Transgenic CRFR1-Cre-2a-tdTom Rat.The Journal of comparative neurology · 2025Article
- Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses.Behavioral and brain functions : BBF · 2025Article
- Heightened subcortical reactivity to uncertain-threat is associated with future internalizing symptoms, conditional on stress exposure.bioRxiv : the preprint server for biology · 2025Article
- Oxytocin in periaqueductal gray plasticly regulates strain-dependent social recognition memory in mice, modeling social identity.Communications biology · 2025Article
- Tonic immobility and phenomenal consciousness in animals: a review.Frontiers in psychology · 2025Review
- Role of Neural Circuits in Cognitive Impairment.Neurochemical research · 2024Review
- The Spiraling Cognitive-Emotional Brain: Combinatorial, Reciprocal, and Reentrant Macro-organization.Journal of cognitive neuroscience · 2024Article
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.Neurobiology of stress · 2024Article
- Behavioral and neural correlates of diverse conditioned fear responses in male and female rats.bioRxiv : the preprint server for biology · 2024Article
- Periaqueductal gray activates antipredatory neural responses in the amygdala of foraging rats.eLife · 2024Article
- A non-image-forming visual circuit mediates the innate fear of heights in male mice.Nature communications · 2024Article
- Noncortical cognition: integration of information for close-proximity behavioral problem-solving.Current opinion in behavioral sciences · 2024Article
- Freud's 1926 conjecture is confirmed: evidence from the dorsal periaqueductal gray in mice that human psychological defense against internal instinctual threat evolved from animal motor defense against external predatory threat.Frontiers in psychology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The midbrain periaqueductal gray (PAG) has been recognized for decades as having a central role in the control of a wide variety of defensive responses. Initial discoveries relied primarily on lesions, electrical stimulation and pharmacology. Recent developments in neural activity imaging and in methods to control activity with anatomical and genetic specificity have revealed additional streams of data informing our understanding of PAG function. Here, we discuss both classic and modern studies reporting on how PAG-centered circuits influence innate as well as learned defensive actions in rodents and humans. Though early discoveries emphasized the PAG's role in rapid induction of innate defensive actions, emerging new data indicate a prominent role for the PAG in more complex processes, including representing behavioral states and influencing fear learning and memory. This article is part of the Special Issue on "Fear, Anxiety and PTSD".
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.