Evidence map›Paper›PMID 36773748›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2023

A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation.

Bridget M Brengle, Michelle Lin, Robyn A Roth, Kara D Jones, Jessica E Wagenseil, Robert P Mecham, Carmen M Halabi

Open access · hybridAbstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Elastin Regulation of Vasoreactivity in Resistance Arteries.Hypertension (Dallas, Tex. : 1979) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bridget M BrengleDepartment of Pediatrics, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA.
Michelle LinDepartment of Pediatrics, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA.
Robyn A RothDepartment of Pediatrics, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA.
Kara D JonesDepartment of Pediatrics, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA.
Jessica E WagenseilDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, USA.
Robert P MechamDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, U.S.A.
Carmen M HalabiDepartment of Pediatrics, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: chalabi@wustl.edu.
Washington University in St. Louis · US

Funding

ASSEMBLY OF LUNG ELASTINR01HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 1995 to 2019
$3.6M
Vascular Extracellular Matrix in Arterial Development and DiseaseK08HL135400 · NHLBI · WASHINGTON UNIVERSITY · PI HALABI, CARMEN M. · 2017 to 2020
$613k
Elastin deposition and stenosis formation in the developing aortaR56HL152420 · NHLBI · WASHINGTON UNIVERSITY · PI WAGENSEIL, JESSICA · 2020 to 2020
$394k
NHLBI NIH HHS K08 HL135400NHLBI NIH HHS R01 HL053325NHLBI NIH HHS R56 HL152420
6 · The paper itself

Abstract

Supravalvular aortic stenosis (SVAS) is an autosomal dominant disease resulting from elastin (ELN) haploinsufficiency. Individuals with SVAS typically develop a thickened arterial media with an increased number of elastic lamellae and smooth muscle cell (SMC) layers and stenosis superior to the aortic valve. A mouse model of SVAS (Eln

Indexed as

Aortic Stenosis, SupravalvularHypertensionAnimalsBlood PressureElastinHaploinsufficiencyHumansMiceMice, Inbred C57BLReninElastinEln protein, mouseReninArterial stiffnessElastin haploinsufficiencyEndothelial dysfunctionHypertensionSupravalvular aortic stenosis

Identifiers

PMID36773748
PMCPMC12074569
OpenAlexW4319659441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.