Evidence map›Paper›PMID 36773674›Full record

ArticleFrontiers in neuroendocrinology2023

The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review.

Lindsey Mountcastle, Melissa Zajdel, Taylor Robinson, Krystyna R Keller, Shani Gelles, Alicia A Livinski, Bijal Kikani, Dawn E Lea, Laura M Koehly

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroendocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lindsey MountcastleSocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute.
Melissa ZajdelSocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute. Electronic address: melissa.zajdel@nih.gov.
Taylor RobinsonSocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute.
Krystyna R KellerSocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute.
Shani GellesSocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute.
Alicia A LivinskiNational Institutes of Health Library, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
Bijal KikaniSocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute.
Dawn E LeaSocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute.
Laura M KoehlySocial Network Methods Section, Social and Behavioral Research Branch, National Human Genome Research Institute.

Funding

Inherited Disease, Caregiving, and Social NetworksZIAHG200395 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KOEHLY, LAURA M · 2015 to 2025
$11.2M
Intramural NIH HHS ZIA HG200395
6 · The paper itself

Abstract

Caregiving has been robustly linked to caregiver health through the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in the context of caregiving for an adult with a chronic illness. However, little research examines the physiological impact of caregiving for a child with a chronic illness despite high burden and unique stressors. In this review, we explore the links of caregiving for a child with a congenital, chromosomal, or genetic disorder to the regulation or dysregulation of the HPA axis. A search was conducted in PubMed, Embase, and the Web of Science and 15 studies met inclusion criteria. Overall, there were inconsistent links of caregiving to HPA axis functioning, perhaps due to the heterogeneity across disease contexts, study designs, and biomarker measurement. Future research should standardize measurement and study designs, increase participant diversity, and examine moderators of the links of caregiving to the HPA axis.

Indexed as

Hypothalamo-Hypophyseal SystemPituitary-Adrenal SystemAdultChildChronic DiseaseHumansStress, PsychologicalCaregivingHPA axisPediatric illnessStress

Identifiers

PMID36773674
PMCPMC10182255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.