Evidence map›Paper›PMID 36773480›Full record

ArticleGait & posture2023

Dopamine replacement therapy normalizes reactive step length to postural perturbations in Parkinson's disease.

Cara Herbers, Joseph Schroeder, Chiahao Lu, Helen Geng, Raymond Zhang, Jessica Mehregan, Kada Malakowsky, Arthur Erdman, Matthew D Johnson, Scott E Cooper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gait & posture, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Cara HerbersDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Joseph SchroederDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Chiahao LuDepartment of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.
Helen GengDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Raymond ZhangDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Jessica MehreganDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Kada MalakowskyDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Arthur ErdmanDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Matthew D JohnsonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Scott E CooperDepartment of Neurology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: secooper@umn.edu.
University of Minnesota · US

Funding

Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI JOHNSON, MATTHEW DOUGLAS · 2016 to 2020
$9.1M
Targeted Pathway Activation for PosturalInstability and Gait Disorder in Parkinson'sDiseaseR01NS124814 · NINDS · UNIVERSITY OF MINNESOTA · PI SCOTT E COOPER · 2022 to 2026
$3.7M
NINDS NIH HHS P50 NS098573NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS124814
6 · The paper itself

Abstract

backgroundPostural instability is one of the most disabling motor symptoms of Parkinson's disease (PD) given its association with falls and loss of independence. Previous studies have assessed biomechanical measures of reactive stepping in response to perturbations, showing that individuals with PD exhibit inadequate postural responses to regain balance. RESEARCH QUESTION: Does dopamine replacement therapy normalize step length in response to balance perturbations?

methodsIn this study, we estimated reactive step length, to a postural perturbation, retrospectively from a dataset of frontal plane video using 2D motion tracking and direct linear transform methods. We compared two perturbation methods: support surface translation and shoulder pull (the clinical standard) in 14 individuals with PD and 13 without PD (on and off medication), with and without partial body weight support (BWS). The primary outcome was the length of the first step taken to regain balance after the perturbation analyzed with mixed effects ANOVA, with post hoc analysis of anteroposterior (AP) and mediolateral (ML) components.

resultsPD OFF medication exhibited shorter reactive step length compared to PD ON and compared to control groups for the surface translation perturbations, but no significant difference was observed for the shoulder pull perturbations. SIGNIFICANCE: Dopamine replacement therapy affects step length in response to perturbation more robustly for surface translations than for a pull by the shoulders.

Indexed as

Parkinson DiseaseDopamineHumansPostural BalanceRetrospective StudiesDopamineBalanceLevodopaParkinson’s diseasePostural InstabilityStep Length

Identifiers

PMID36773480
PMCPMC10023411
OpenAlexW4318561964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.