Evidence map›Paper›PMID 36773106›Full record

ArticleActa neuropathologica2023

Retinal pathological features and proteome signatures of Alzheimer's disease.

Yosef Koronyo, Altan Rentsendorj, Nazanin Mirzaei, Giovanna C Regis, Julia Sheyn, Haoshen Shi, Ernesto Barron, Galen Cook-Wiens, Anthony R Rodriguez, Rodrigo Medeiros and 16 more

Open access · hybridFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 3 pooled it
24.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 3 syntheses or guidelines pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  8. Retinal Vascularity Index in Mild Cognitive Impairment.Translational vision science & technology · 2026
    Article
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 3 countries.

Yosef Koronyo *Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Altan Rentsendorj *Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Nazanin Mirzaei *Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Giovanna C RegisDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Julia SheynDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Haoshen ShiDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Ernesto BarronDoheny Eye Institute, University of California Los Angeles, Los Angeles, CA, USA.
Galen Cook-WiensBiostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Anthony R RodriguezNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rodrigo MedeirosClem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, USA.
Veer B GuptaSchool of Medicine, Deakin University, Victoria, Australia.
Andrei A KramerovDepartment of Biomedical Sciences and Eye Program, Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alexander V LjubimovDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Jennifer E Van EykDepartments of Neurology and Biomedical Sciences, Division of Applied Cell Biology and Physiology, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, USA.
Stuart L GrahamSave Sight Institute, University of Sydney, Sydney, NSW, Australia.
Vivek K GuptaMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
John M RingmanDepartment of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.
David R Hinton *Departments of Pathology and Ophthalmology, Keck School of Medicine, USC Roski Eye Institute, University of Southern California, Los Angeles, CA, USA.
Carol A MillerDepartment of Pathology Program in Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Keith L BlackDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Antonino CattaneoEuropean Brain Research Institute (EBRI), Viale Regina Elena, Rome, Italy.
Giovanni MeliEuropean Brain Research Institute (EBRI), Viale Regina Elena, Rome, Italy.
Mehdi MirzaeiMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Dieu-Trang FuchsDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA.
Maya Koronyo-HamaouiDepartment of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Los Angeles, CA, 90048, USA. maya.koronyo@csmc.edu.ORCID 0000-0003-2864-8442
Cedars-Sinai Medical Center · USUniversity of Southern California · USDeakin University · AUEuropean Brain Research Institute · ITHarvard University · USKeck Hospital of USC · USMacquarie University · AUThe University of Queensland · AUThe University of Sydney · AUUniversity of California, Los Angeles · US

Funding

The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Mechanisms of Epithelial Alterations in Diabetic CorneaR01EY013431 · NEI · CEDARS-SINAI MEDICAL CENTER · PI Alexander V Ljubimov · 2001 to 2026
$11.3M
Alzheimer's Disease Hallmark Pathology and Associated Inflammation in the RetinaR01AG055865 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Maya Koronyo-Hamaoui · 2018 to 2026
$4.9M
Motor, Visual, and Olfactory Changes in Genetic Subtypes of Alzheimer’s DiseaseR01AG062007 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RINGMAN, JOHN M · 2019 to 2023
$4.1M
Retinal Imaging of Alzheimer's Disease PathologyR01AG056478 · NIA · CEDARS-SINAI MEDICAL CENTER · PI KORONYO-HAMAOUI, MAYA · 2017 to 2021
$2.5M
Advancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7M
NEI NIH HHS R01 EY013431NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG055865NIA NIH HHS R01 AG056478NIA NIH HHS R01 AG062007NIGMS NIH HHS R01 GM132129
6 · The paper itself

Abstract

Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progression in the brain remain largely unknown. To better understand the pathological features of AD in the retina, we conducted an extensive histopathological and biochemical investigation of postmortem retina and brain tissues from 86 human donors. Quantitative examination of superior and inferior temporal retinas from mild cognitive impairment (MCI) and AD patients compared to those with normal cognition (NC) revealed significant increases in amyloid β-protein (Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAtrophyBiomarkersFemaleHumansMaleProteomeProteomicsRetinaAmyloid beta-PeptidesBiomarkersProteomeEyeGFAPIBA1Immune responsesNeurodegenerative disordersOcular abnormalitiesS100βscFvA13-intraneuronal oligomers

Identifiers

PMID36773106
PMCPMC10020290
OpenAlexW4320033104

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read118
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.