Evidence map›Paper›PMID 36773064›Full record

ArticleHuman genetics2023

Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis.

Salvatore D'Antona, Gita A Pathak, Dora Koller, Danilo Porro, Claudia Cava, Renato Polimanti

Abstract read
In one paragraph

Article in Human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Salvatore D'AntonaInstitute of Bioimaging and Molecular Physiology, National Research Council, Milan, Italy.
Gita A PathakDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Dora KollerDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Danilo PorroInstitute of Bioimaging and Molecular Physiology, National Research Council, Milan, Italy.
Claudia CavaInstitute of Bioimaging and Molecular Physiology, National Research Council, Milan, Italy. claudia.cava@ibfm.cnr.it.
Renato PolimantiDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0745-6046

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
Leveraging genomic data to dissect the association of internalizing disorders with the risk, onset, and vulnerability of COVID-19RF1MH132337 · NIMH · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2022 to 2022
$3.7M
Investigating the Systems Genetics of the Patterns of Polysubstance Abuse and AddictionR33DA047527 · NIDA · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2021 to 2023
$2.0M
Genome-wide Investigation of the Interplay Between Age-Related Hearing Loss and Smoking BehaviorsR21DC018098 · NIDCD · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2019 to 2021
$440k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R33 DA047527NIDCD NIH HHS R21 DC018098NIMH NIH HHS RF1 MH132337NIMH NIH HHS T32 MH014276
6 · The paper itself

Abstract

Leveraging genome-wide association statistics generated from a large study of amyotrophic lateral sclerosis (ALS; 29,612 cases and 122,656 controls) and UK Biobank (UKB; 4,024 phenotypes, up to 361,194 participants), we conducted a phenome-wide analysis of ALS genetic liability and identified 46 genetically correlated traits, such as fluid intelligence score (r

Indexed as

Amyotrophic Lateral SclerosisDuodenitisGastritisGenome-Wide Association StudyHumansMendelian Randomization AnalysisPhenotype

Identifiers

PMID36773064
PMCPMC10449723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.