Evidence map›Paper›PMID 36773035›Full record

ArticleThe international journal of cardiovascular imaging2023

Influence of heart rate and heart rate variability on the feasibility of ultra-fast, high-pitch coronary photon-counting computed tomography angiography.

Lukas T Rotkopf, Matthias F Froelich, Philipp Riffel, Christian H Ziener, Carissa Reid, Heinz-Peter Schlemmer, Stefan O Schoenberg, Isabelle Ayx

Abstract read
In one paragraph

Article in The international journal of cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A scoping review of photon-counting detector computed tomography in cardiovascular imaging.Diagnostic and interventional radiology (Ankara, Turkey) · 2026
    Article
  2. Cardiac imaging using photon counting CT - benefits, challenges and prospects.The international journal of cardiovascular imaging · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lukas T RotkopfDepartment of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Matthias F FroelichDepartment of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Philipp RiffelDepartment of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Christian H ZienerDepartment of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Carissa ReidDivision of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Heinz-Peter SchlemmerDepartment of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Stefan O SchoenbergDepartment of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Isabelle AyxDepartment of Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. isabelle.ayx@medma.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary computed tomography angiography has become a mainstay in diagnosing coronary artery disease and is increasingly used in screening symptomatic patients. Recently, photon-counting computed tomography (PCCT) has been introduced into clinical practice, offering higher spatial and temporal resolution. As the applied radiation dose is highly dependent on the choice of scan mode and is lowest using the ultra-fast high-pitch (FLASH) mode, guidelines for their application are needed. From a retrospective study investigating the properties of a novel photon-counting computed tomography, all patients who underwent FLASH-mode PCCT angiography were selected between January and April 2022. This resulted in a study population of 46 men and 27 women. We recorded pre- and intrascan ECG readings and calculated heart rate (maximum heart rate 73 bpm) as well heart rate variability (maximum HRV 37 bpm) as measured by the standard deviation of the heart rate. Diagnostic quality and motion artifacts scores were recorded for each coronary artery segment by consensus between two readers. We found a highly significant association between heart rate variability and image quality (p < 0.001). The heart rate itself was not independently associated with image quality. Both heart rate and heart rate variability were significantly associated with the presence of motion artifacts in a combined model. Scan heart rate variability-but not heart rate itself-is a highly significant predictor of reduced image quality on high-pitch coronary photon-counting computed tomography angiography. This may be due to better scanner architecture and an increased temporal resolution compared to conventional energy-integrating detector computed tomography, which has to be addressed in a comparison study in the future.

Indexed as

Computed Tomography AngiographyCoronary AngiographyFeasibility StudiesFemaleHeart RateHumansMalePredictive Value of TestsRadiation DosageRetrospective StudiesDose reductionFLASH modeHeart rateImage qualityPhoton-counting detector CT

Identifiers

PMID36773035
PMCPMC10160151

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.