Evidence map›Paper›PMID 36772084›Full record

ArticlePolymers2023

The Fabrication of Gelatin-Elastin-Nanocellulose Composite Bioscaffold as a Potential Acellular Skin Substitute.

Ahmad Mus'ab Ahmad Hariza, Mohd Heikal Mohd Yunus, Mh Busra Fauzi, Jaya Kumar Murthy, Yasuhiko Tabata, Yosuke Hiraoka

Abstract read
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmad Mus'ab Ahmad HarizaDepartment of Physiology, Faculty of Medicine, UKM Medical Centre, Jalan Yaacob Latiff, Kuala Lumpur 56000, Malaysia.
Mohd Heikal Mohd YunusDepartment of Physiology, Faculty of Medicine, UKM Medical Centre, Jalan Yaacob Latiff, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-6793-2043
Mh Busra FauziCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0001-6449-639X
Jaya Kumar MurthyDepartment of Physiology, Faculty of Medicine, UKM Medical Centre, Jalan Yaacob Latiff, Kuala Lumpur 56000, Malaysia.
Yasuhiko TabataLaboratory of Biomaterials, Department of Regeneration Science and Engineering, Institute for Life and Medical Science (LiMe), Kyoto University, 53 Kawara-cho Shogoin, Sakyo-Ku, Kyoto 606-8500, Japan.
Yosuke HiraokaBiomaterial Group, R&D Centre, Nitta Gelatin Inc., 2-22, Futamata, Yao City 581-0024, Japan.

Funding

University Kebangsaan Malaysia Medical Centre FF2019-538
6 · The paper itself

Abstract

Gelatin usage in scaffold fabrication is limited due to its lack of enzymatic and thermal resistance, as well as its mechanical weakness. Hence, gelatin requires crosslinking and reinforcement with other materials. This study aimed to fabricate and characterise composite scaffolds composed of gelatin, elastin, and cellulose nanocrystals (CNC) and crosslinked with genipin. The scaffolds were fabricated using the freeze-drying method. The composite scaffolds were composed of different concentrations of CNC, whereas scaffolds made of pure gelatin and a gelatin-elastin mixture served as controls. The physicochemical and mechanical properties of the scaffolds, and their cellular biocompatibility with human dermal fibroblasts (HDF), were evaluated. The composite scaffolds demonstrated higher porosity and swelling capacity and improved enzymatic resistance compared to the controls. Although the group with 0.5% (

Indexed as

composite bioscaffoldelastingelatinnanocelluloseskin substitute

Identifiers

PMID36772084
PMCPMC9920652

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.