ReviewPlants (Basel, Switzerland)2023
Friends in Arms: Flavonoids and the Auxin/Cytokinin Balance in Terrestrialization.
Review in Plants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Functional analysis ofPlant signaling & behavior · 2026Article
- Beneficial bacterial inoculation modulates hormonal-redox responses associated with enhanced floral volatile biosynthesis in Rosa damascena.World journal of microbiology & biotechnology · 2026Article
- CRISPR/Cas9-mediated DFR disruption suggests coordinated changes in flavonoid flux and development in Petunia × hybrida.Plant cell reports · 2026Article
- Evolutionary Repurposing of Cytokinin Signaling in Plant Development and Symbiosis.Plants (Basel, Switzerland) · 2026Review
- The Antimicrobial and Cytotoxicity Properties of New Dibrominated 1,3-Dithiolium Flavonoids.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications.Angewandte Chemie (International ed. in English) · 2026Review
- Comprehensive review of biosynthesis, plant function, metabolism and new therapeutic bioactivities of flavonoids.ADMET & DMPK · 2026Review
- Phenylalanine Ammonia-Lyase: A Core Regulator of Plant Carbon Metabolic Flux Redistribution-From Molecular Mechanisms and Growth Modulation to Stress Adaptability.Plants (Basel, Switzerland) · 2025Review
- Downregulation of chalcone isomerase in Petunia hybrida: profound effects on floral morphology and transcriptional remodeling of the flavonoid biosynthetic pathway.BMC plant biology · 2025Article
- The Evolution of Plant Hormones: From Metabolic Byproducts to Regulatory Hubs.International journal of molecular sciences · 2025Review
- Blue-Red LED Light Modulates Morphophysiological and Metabolic Responses in the Medicinal PlantPlants (Basel, Switzerland) · 2025Article
- The role of cytokinin receptors in Arabidopsis thaliana seed development and how they affect the metabolomic profile.Planta · 2025Article
- Weighted gene co-expression network analysis - based selection of hub genes related to phenolic and volatile compounds and seed coat color in sorghum.BMC plant biology · 2025Article
- Antibacterial and Antifungal Properties of New Synthetic Tricyclic Flavonoids.Antibiotics (Basel, Switzerland) · 2025Article
- Antioxidants by nature: an ancient feature at the heart of flavonoids' multifunctionality.The New phytologist · 2025Article
- Genomic analyses of 238 seed plants reveal the evolutionary mechanisms driving specialization of F3H, ANS, and FLS in flavonoid biosynthesis.Frontiers in plant science · 2025Article
- Co-option of plant gene regulatory network in nutrient responses during terrestrialization.Nature plants · 2024Article
- The evolution of flavonoid biosynthesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- PmLBD3 links auxin and brassinosteroid signalling pathways on dwarfism in Prunus mume.BMC biology · 2024Article
- A Structure-Activity Relationship Study on the Antioxidant Properties of Dithiocarbamic Flavanones.Antioxidants (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Land plants survive the challenges of new environments by evolving mechanisms that protect them from excess irradiation, nutrient deficiency, and temperature and water availability fluctuations. One such evolved mechanism is the regulation of the shoot/root growth ratio in response to water and nutrient availability by balancing the actions of the hormones auxin and cytokinin. Plant terrestrialization co-occurred with a dramatic expansion in secondary metabolism, particularly with the evolution and establishment of the flavonoid biosynthetic pathway. Flavonoid biosynthesis is responsive to a wide range of stresses, and the numerous synthesized flavonoid species offer two main evolutionary advantages to land plants. First, flavonoids are antioxidants and thus defend plants against those adverse conditions that lead to the overproduction of reactive oxygen species. Second, flavonoids aid in protecting plants against water and nutrient deficiency by modulating root development and establishing symbiotic relations with beneficial soil fungi and bacteria. Here, we review different aspects of the relationships between the auxin/cytokinin module and flavonoids. The current body of knowledge suggests that whereas both auxin and cytokinin regulate flavonoid biosynthesis, flavonoids act to fine-tune only auxin, which in turn regulates cytokinin action. This conclusion agrees with the established master regulatory function of auxin in controlling the shoot/root growth ratio.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.