Evidence map›Paper›PMID 36771397›Full record

ArticleNutrients2023

The Effects of Iron Deficiency on the Gut Microbiota in Women of Childbearing Age.

Hoonhee Seo, Seug Yun Yoon, Asad Ul-Haq, Sujin Jo, Sukyung Kim, Md Abdur Rahim, Hyun-A Park, Fatemeh Ghorbanian, Min Jung Kim, Min-Young Lee and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06521879 (Improved Gastrointestinal Tolerance and Iron Status Via Probiotic Use in Iron Deficiency Anemia Patients Initiating Oral Iron Replacement), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06521879 nacompletednot on this map

Improved Gastrointestinal Tolerance and Iron Status Via Probiotic Use in Iron Deficiency Anemia Patients Initiating Oral Iron Replacement

TypeinterventionalSponsorAntalya Training and Research HospitalRan2022 to 2023Enrolled295ConditionsIron Deficiency Anemia Treatment, Iron Deficiency AnemiaArmsLactobacillus plantarum 299v probiotic support
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  12. Food as Medicine for Hypertension: Microbiota as Mediators.Hypertension (Dallas, Tex. : 1979) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hoonhee SeoProbiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of Korea.
Seug Yun YoonDivision of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.ORCID 0000-0001-8228-0218
Asad Ul-HaqProbiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of Korea.ORCID 0000-0002-3602-7980
Sujin JoDepartment of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea.ORCID 0000-0002-1260-7702
Sukyung KimProbiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of Korea.
Md Abdur RahimDepartment of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea.
Hyun-A ParkDepartment of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea.ORCID 0000-0002-9148-4535
Fatemeh GhorbanianDepartment of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan-si 31151, Republic of Korea.
Min Jung KimDivision of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.
Min-Young LeeDivision of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.
Kyoung Ha KimDivision of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.ORCID 0000-0001-8842-4761
Namsu LeeDivision of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.
Jong-Ho WonDivision of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.
Ho-Yeon SongProbiotics Microbiome Convergence Center, Soonchunhyang University, Asan-si 31538, Republic of Korea.

Funding

National Research Foundation of Korea 2021R1G1A1094322Soonchunhyang University Soonchunhyang University Research Fund.Technology Innovation program 20018499
6 · The paper itself

Abstract

Iron deficiency anemia (IDA) is the most prevalent and common nutritional deficiency worldwide and is a global health problem with significant risk, particularly among women of reproductive age. Oral iron supplementation is the most widely used and cost-effective treatment for iron deficiency and IDA. However, there are limitations regarding side effects such as enteritis, treatment compliance, and bioavailability. Intestinal microbiome characteristic research has been recently conducted to overcome these issues, but more is needed. Against this background, a metagenomics study on the 16S gene in the feces of young women vulnerable to IDA was conducted. As a result of analyzing 16 normal subjects and 15 IDA patients, significant differences in bacterial community distribution were identified. In particular, a significant decrease in

Indexed as

Anemia, Iron-DeficiencyGastrointestinal MicrobiomeIron DeficienciesMicrobiotaFemaleHumansIronIron16S rRNA gene-based metagenomicsdysbiosisgut microbiomeiron-deficiency anemia (IDA)next-generation sequencing (NGS)young women

Identifiers

PMID36771397
PMCPMC9919165

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.