ReviewNutrients2023
Infantile Colic and Long-Term Outcomes in Childhood: A Narrative Synthesis of the Evidence.
Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- The Role of Inflammation in Infant Colic-A Systematic Review and Meta-Analysis.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- Comparative efficacy of probiotic mixture Bifidobacterium longum KABP042 plus Pediococcus pentosaceus KABP041 vs. Limosilactobacillus reuteri DSM17938 in the management of infant colic: a randomized clinical trial.European journal of pediatrics · 2024Trial
- A synbiotic mixture for the management of infantile colic: A randomized trial.European journal of pediatrics · 2024Trial
- Evaluating the influence of parental atopy on the effectiveness of a maternal dairy-free diet in alleviating infantile colic: a before-and-after study.BMC pediatrics · 2024Trial
- Early Childhood Obesity: Multifactorial Influences with a Prominent Familial ContributionJournal of clinical research in pediatric endocrinology · 2026Article
- Percentiles for crying, regurgitation, stool consistency, and CoMiSSPediatric research · 2026Article
- Associations of Colic and Excessive Crying in Infancy with Food Allergy Outcomes in Childhood and Adolescence.The Journal of pediatrics · 2026Article
- Green Stool Predominance in Babies and Subsequent Bowel Function at 1-2 Years of Age.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Antibiotics in the first week of life are not associated with functional gastrointestinal disorders at 9-12 years of age.Journal of pediatric gastroenterology and nutrition · 2026Observational
- The Gut in Early Life-Postnatal Challenges.Children (Basel, Switzerland) · 2026Review
- Exclusive breastfeeding and infantile colic: a cohort study.International breastfeeding journal · 2026Article
- The effect of infantile colic training given to parents on the neonatal infantile colic level and crying duration.Scientific reports · 2026Article
- Risk factors and long-term outcomes of infantile colic: A nationwide population-based study.Scientific reports · 2026Article
- Associations of cord blood biomarkers with infant colic and excessive crying.Frontiers in pediatrics · 2026Article
- Infantile Colic: When to Suspect Cow's Milk Allergy.Nutrients · 2025Review
- The Maternal Support Framework Studying Mothers' Perceived Understanding and Support During Excessive Infant Crying: Exploratory Qualitative Study.JMIR pediatrics and parenting · 2025Article
- Supplementation of 2'-Fucosyllactose in Formula-Fed Infants Has Potential Benefits to Reduce the Risks of Infantile Colic and Atopic Dermatitis in Infancy.Pediatric gastroenterology, hepatology & nutrition · 2025Article
- Association between maternal migraine and infantile colic: a narrative review.BMC pediatrics · 2025Review
- Associations of Infant Colic and Excessive Crying With Atopic Outcomes in Childhood and Adolescence.The Journal of pediatrics · 2025Article
- Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders.World journal of clinical pediatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
About 1 in 4 infants comes forward with prolonged crying, agitation, or infant colic (IC) during the first three months of life and is referred for medical evaluation. The pathogenesis remains poorly understood, as do its implications for future health. The aim of this narrative review was to critically examine and discuss the available literature on long-term consequences of excessive crying and/or colic. Most studies display an association between IC and the onset of functional gastrointestinal disorders (FGIDs) years later, probably related to the presence of common etiopathogenetic factors (environmental, dietary, intestinal dysmotility, visceral hypersensitivity). Although allergic disease in first-degree relatives may be a risk factor for IC, the latter does not appear to be a risk factor for subsequent atopic disease in the individual. Overall, there seems to be a relationship between IC and subsequent headaches, of the migraine type. Similarly, behavioral problems in children with a history of IC appear to be associated with higher parental stress scores. However, the current evidence is based on associations, and currently, a causal relationship between excessive crying and IC and long-term consequences remains not documented.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.