Evidence map›Paper›PMID 36771307›Full record

Observational studyNutrients2023

Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes.

Josip Delmis, Slavko Oreskovic, Vesna Elvedji Gasparovic, Mirta Starcevic, Mislav Herman, Nada Dessardo, Vito Starcevic, Marina Ivanisevic

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Josip DelmisDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-7332-5936
Slavko OreskovicDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Vesna Elvedji GasparovicDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0002-0960-3989
Mirta StarcevicDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Mislav HermanDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Nada DessardoDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Vito StarcevicDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Marina IvanisevicDepartment of Obstetrics and Gynecology, University Hospital Medical Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.ORCID 0000-0001-6478-1174

Funding

CROATIAN SCIENCE FOUNDATION PRE-HYPO No. IP-2018-01-1284.
6 · The paper itself

Abstract

The study aimed to determine the relationship between glucose, C-peptide, brain-derived neurotrophic factor (BDNF), and leptin between mother and fetus and neonatal weight.

methodsIn the prospective observational cohort study, we included 66 women with type-1 diabetes mellitus (T1DM). According to the z-score for neonatal weight, patients were divided into healthy-weight neonates (

resultsA strong correlation was confirmed between maternal and umbilical vein glucose concentration and maternal glucose and C-peptide in umbilical vein blood. A negative correlation was found between the concentration of BDNF in the umbilical vein and glucose in maternal blood. A strong correlation was seen between BMI and maternal blood leptin concentration, neonatal fat body mass, and umbilical vein blood leptin concentration. Higher BMI elevated BDNF, and TSH increase the odds for overweight neonates in the first trimester of pregnancy. Maternal higher leptin concentration in the first trimester decrease the odds of overweight neonates.

conclusionsMaternal glucose concentrations affect the fetus's glucose, C-peptide, and BDNF concentrations. Leptin levels increase in maternal blood due to increased body mass index, and in the neonate, fat body mass is responsible for increased leptin concentrations.

Indexed as

Diabetes Mellitus, Type 1LeptinBody Mass IndexBrain-Derived Neurotrophic FactorCesarean SectionC-PeptideFemaleFetal BloodGlucoseHumansInfant, NewbornOverweightPregnancyProspective StudiesThyrotropinUmbilical VeinsBrain-Derived Neurotrophic FactorC-PeptideGlucoseLeptinThyrotropinBDNFC-peptideCRPleptinpregnancyskinfold thicknessthyroid hormonestype-1 diabetes mellitus

Identifiers

PMID36771307
PMCPMC9919383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.