Evidence map›Paper›PMID 36771252›Full record

Observational studyNutrients2023

Hepcidin Status in Cord Blood: Observational Data from a Tertiary Institution in Belgium.

Michael Ceulemans, Joline Van de Vel, Dorine W Swinkels, Coby M M Laarakkers, Jaak Billen, Kristel Van Calsteren, Karel Allegaert

Abstract readObservational Study
In one paragraph

Observational study in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael CeulemansClinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-4130-5869
Joline Van de VelFaculty of Pharmaceutical Sciences, KU Leuven, 3000 Leuven, Belgium.
Dorine W SwinkelsTranslational Metabolic Laboratory (TML 830), Department of Laboratory Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.ORCID 0000-0002-1040-9446
Coby M M LaarakkersTranslational Metabolic Laboratory (TML 830), Department of Laboratory Medicine, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Jaak BillenDepartment of Laboratory Medicine, University Hospitals Leuven Gasthuisberg, 3000 Leuven, Belgium.
Kristel Van CalsterenDepartment of Obstetrics & Gynecology, University Hospitals Leuven Gasthuisberg, 3000 Leuven, Belgium.ORCID 0000-0002-2438-6783
Karel AllegaertClinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-9921-5105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hormone hepcidin plays an important role in intestinal iron absorption and cellular release. Cord blood hepcidin values reflect fetal hepcidin status, at least at the time of delivery, but are not available for the Belgian population. Therefore, we aimed (1) to provide the first data on cord blood hepcidin levels in a Belgian cohort and (2) to determine variables associated with cord blood hepcidin concentrations. A cross-sectional, observational study was performed at the University Hospital Leuven, Belgium. Cord blood samples were analyzed using a combination of weak cation exchange chromatography and time-of-flight mass spectrometry. Descriptive statistics, Spearman correlation tests, and Mann-Whitney U tests were performed. In total, 61 nonhemolyzed cord blood samples were analyzed. The median hepcidin level was 17.6 μg/L (IQR: 18.1; min-max: 3.9-54.7). A moderate correlation was observed between cord blood hepcidin and cord blood ferritin (r = 0.493) and hemoglobin (r = -0.342). Cord blood hepcidin was also associated with mode of delivery (

Indexed as

Fetal BloodHepcidinsBelgiumCross-Sectional StudiesFemaleHumansIronPregnancyHepcidinsIroncord bloodhepcidinsiron regulationiron statuspregnancy

Identifiers

PMID36771252
PMCPMC9920610

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.