ReviewNutrients2023
The Role of Maternal Vitamin D Deficiency in Offspring Obesity: A Narrative Review.
Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Effect of probiotic administration during pregnancy on the functional diversity of the gut microbiota in healthy pregnant women.Microbiology spectrum · 2024Trial
- Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights.Current nutrition reports · 2026Review
- Investigating the Association Between Serum 25-Hydroxyvitamin D (25(OH)D) and Body Mass Index (BMI) With In Vitro Fertilization (IVF) Outcomes Among Iranian Women: A Case-Control Study.Health science reports · 2026Article
- Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences.Cells · 2026Review
- Vitamin D and the metabolic-associated steatotic liver disease-type 2 diabetes axis: a scoping-narrative review of global evidence and emerging perspectives for Sub-Saharan Africa.Frontiers in epidemiology · 2026Review
- Early-Life Nutritional Determinants of Pediatric MASLD.Nutrients · 2025Review
- Prevalence and determinants of hypovitaminosis D in early pregnancy: a cross-sectional study among first-trimester pregnant women.BMC pregnancy and childbirth · 2025Article
- Vitamin D deficiency in a subfertility population and the impact of COVID-19 lockdowns.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- The Essential Role of Vitamin D in Pediatric Health: Implications for Oropharyngeal Infections and Neutropenia-Associated Vulnerability.Children (Basel, Switzerland) · 2025Article
- Vitamin D Deficiency and Risk of Gestational Diabetes Mellitus in Western Countries: A Scoping Review.Nutrients · 2025Article
- Lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring.Journal of molecular endocrinology · 2025Article
- Childhood Obesity: A Narrative Review.Cureus · 2025Review
- Association of nutrient intake and dietary patterns with serum folate and anemia-related biomarkers in Taiwanese pregnant women with pre-pregnancy overweightness or obesity.International journal of medical sciences · 2025Article
- Vitamin D Deficiency and Maternal Diseases as Risk Factors for the Development of Macrosomia in Newborns.Children (Basel, Switzerland) · 2024Article
- Close Adherence to a Mediterranean Diet during Pregnancy Decreases Childhood Overweight/Obesity: A Prospective Study.Nutrients · 2024Article
- Combination effects of environmental tobacco smoke exposure and nutrients supplement during pregnancy on obesity in Chinese preschool children.Frontiers in pediatrics · 2024Article
- Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function.Nutrients · 2023Review
- The Effect of Maternal Dietary Patterns on Birth Weight for Gestational Age: Findings from the MAMI-MED Cohort.Nutrients · 2023Article
- The effect of maternal vitamin D deficiency during pregnancy on glycolipid metabolism of offspring rats and the improvement of vitamin D intervention after weaning.Frontiers in nutrition · 2023Article
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Authors and funding
4 authors.
Funding
Abstract
Currently, vitamin D (VD) deficiency during pregnancy is widespread globally, causing unfavorable pregnancy outcomes for both mothers and infants for a longer time than expected, based on the Developmental Origins of Health and Disease (DOHaD) theory. As VD plays a key role in maintaining normal glucose and lipid metabolism, maternal VD deficiency may lead to obesity and other obesity-related diseases among offspring later in life. This review mainly focuses on the effect of maternal VD deficiency on offspring lipid metabolism, reviewing previous clinical and animal studies to determine the effects of maternal VD deficit on offspring obesity and potential mechanisms involved in the progression of offspring obesity. Emerging clinical evidence shows that a low VD level may lead to abnormal growth (either growth restriction or largeness for gestational age) and lipid and glucose metabolism disorders in offspring. Here, we also outline the link between maternal VD deficiency and life-long offspring effects, including the disorder of adipogenesis, the secretion of adipocytokines (including leptin, resistin, and adiponectin), activated systemic inflammation, increased oxidative reactions in adipose tissue, insulin resistance, and abnormal intestinal gut microbiota. Thus, there is an urgent need to take active steps to address maternal VD deficiency to relieve the global burden of obesity.
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