Evidence map›Paper›PMID 36771200›Full record

ArticleNutrients2023

Savory Signaling: T1R Umami Receptor Modulates Endoplasmic Reticulum Calcium Store Content and Release Dynamics in Airway Epithelial Cells.

Derek B McMahon, Jennifer F Jolivert, Li Eon Kuek, Nithin D Adappa, James N Palmer, Robert J Lee

Abstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Extragustatory bitter taste receptors in head and neck health and disease.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Derek B McMahonDepartment of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2068-5890
Jennifer F JolivertDepartment of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Li Eon KuekDepartment of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nithin D AdappaDepartment of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James N PalmerDepartment of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Robert J LeeDepartment of Otorhinolaryngology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5826-6686

Funding

Immune function of bitter taste receptors in human macrophagesR01AI167971 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Nithin Adappa, Robert J. Lee · 2022 to 2026
$2.5M
Bitter and sweet taste receptor physiology in airway ciliated cellsR01DC016309 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI LEE, ROBERT J. · 2018 to 2022
$2.1M
Cystic Fibrosis Foundation LEE21G0National Institute of Allergy and Infectious Diseases AI167971National Institute on Deafness and Other Communication Disorders DC016309NIAID NIH HHS R01 AI167971NIDCD NIH HHS R01 DC016309
6 · The paper itself

Abstract

T1Rs are expressed in solitary chemosensory cells of the upper airway where they detect apical glucose levels and repress bitter taste receptor Ca

Indexed as

CalciumReceptors, G-Protein-CoupledAmino AcidsCalcium, DietaryEndoplasmic ReticulumEpithelial CellsGlucoseTasteAmino AcidsCalciumCalcium, DietaryGlucoseReceptors, G-Protein-Coupledairwayamino acidsapoptosisT1R1T1R3umami

Identifiers

PMID36771200
PMCPMC9919336

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.