Evidence map›Paper›PMID 36771089›Full record

ArticleMolecules (Basel, Switzerland)2023

Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized

Peter Schmidt, Alexander Vogel, Benedikt Schwarze, Florian Seufert, Kai Licha, Virginia Wycisk, Wolfgang Kilian, Peter W Hildebrand, Lorenz Mitschang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter SchmidtInstitute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany.
Alexander VogelInstitute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany.ORCID 0000-0001-8882-6410
Benedikt SchwarzeInstitute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany.ORCID 0000-0002-5815-8703
Florian SeufertInstitute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany.ORCID 0000-0002-0664-7169
Kai LichaInstitute of Chemistry and Biochemistry, Freie Universitaet Berlin, Takustrasse 3, 14195 Berlin, Germany.
Virginia WyciskInstitute of Chemistry and Biochemistry, Freie Universitaet Berlin, Takustrasse 3, 14195 Berlin, Germany.ORCID 0000-0002-3683-6913
Wolfgang KilianPhysikalisch-Technische Bundesanstalt Braunschweig und Berlin (PTB), Abbestrasse 2-12, 10587 Berlin, Germany.
Peter W HildebrandInstitute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany.ORCID 0000-0003-0063-1104
Lorenz MitschangPhysikalisch-Technische Bundesanstalt Braunschweig und Berlin (PTB), Abbestrasse 2-12, 10587 Berlin, Germany.

Funding

Deutsche Forschungsgemeinschaft CRC1423, project number 421152132, subprojects A03 and Z04
6 · The paper itself

Abstract

G protein-coupled receptors can adopt many different conformational states, each of them exhibiting different restraints towards downstream signaling pathways. One promising strategy to identify and quantify this conformational landscape is to introduce a cysteine at a receptor site sensitive to different states and label this cysteine with a probe for detection. Here, the application of NMR of hyperpolarized

Indexed as

CysteineMagnetic Resonance ImagingHumansLigandsMagnetic Resonance SpectroscopyNeuropeptide YXenonCysteineLigandsNeuropeptide YXenonGPCR stateshyperpolarized xenonMD simulationNMRY2R

Identifiers

PMID36771089
PMCPMC9919357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.