Evidence map›Paper›PMID 36770936›Full record

ArticleMolecules (Basel, Switzerland)2023

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-

Lamya H Al-Wahaibi, Anber F Mohammed, Mostafa H Abdelrahman, Laurent Trembleau, Bahaa G M Youssif

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Bisindole Compounds-Synthesis and Medicinal Properties.Antibiotics (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Anber F MohammedPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.ORCID 0000-0002-4005-982X
Mostafa H AbdelrahmanPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Laurent TrembleauSchool of Natural and Computing Sciences, University of Aberdeen, Meston Building, Aberdeen AB24 3UE, UK.
Bahaa G M YoussifPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.ORCID 0000-0002-6834-6548
Assiut University · EGAl-Azhar University · EGPrincess Nourah bint Abdulrahman University · SAUniversity of Aberdeen · GB

Funding

Princess Nourah bint Abdulrahman University PNURSP2023R3
6 · The paper itself

Abstract

Mutant EGFR/BRAF pathways are thought to be crucial targets for the development of anticancer drugs since they are over-activated in several malignancies. We present here the development of a novel series of 5-chloro-indole-2-carboxylate

Indexed as

Antineoplastic AgentsLung NeoplasmsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorErbB ReceptorsErlotinib HydrochlorideHumansIndolesMolecular Docking SimulationMolecular StructureMutationProtein Kinase InhibitorsProto-Oncogene Proteins B-rafStructure-Activity RelationshipAntineoplastic AgentsBRAF protein, humanEGFR protein, humanErbB ReceptorsErlotinib Hydrochlorideindole-2-carboxylateIndolesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafanticancerBRAFV600Eindolemelanomamutant EGFRpyrrole

Identifiers

PMID36770936
PMCPMC9921301
OpenAlexW4318466534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.